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	Provedor de dados BJMBR (2) Genet. Mol. Biol. (1) Autor Dong,Xia (1) Eguchi,S. (1) Inagami,T. (1) Leng,Xi-gang (1) Liu,Lan-xia (1) Song,Li-ping (1) Touyz,R.M. (1) Zhang,Hai-ling (1) Zhu,Dun-wan (1) Mais... Palavra-chave Vascular smooth muscle cells (3) Angiotensin II (1) Apoptosis (1) Epidermal growth factor receptor (1) Inflammation (1) Reactive oxygen species (1) Remodeling (1) Signal transduction (1) Tissue factor pathway inhibitor (1) Type 1 receptor (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2011 (1) 2004 (1) 2000 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Angiotensin II-mediated vascular smooth muscle cell growth signaling BJMBR Inagami,T.; Eguchi,S.. The mechanism by which Ang II stimulates the growth of vascular smooth muscle cells was investigated by measuring the phosphorylation of mitogen-activated protein kinases ERK 1 and ERK 2. Ca2+ ionophore was found to have effects practically analogous to Ang II. We found that the signaling pathway involves the activation of epidermal growth factor receptor (EGFR) kinase, activation of the adaptor proteins Shc and Grb2, and the small G-protein Ras. Although the mechanism of AT1- (or Ca2+)-induced activation of EGFR is not yet clear, we have found that calcium-dependent protein kinase CAKß/PYK2 and c-Src are involved in this process. These studies indicate a transactivation mechanism that utilizes EGFR as a bridge between a Gq-coupled receptor and activation... Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiotensin II; Type 1 receptor; Epidermal growth factor receptor; Vascular smooth muscle cells. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600002 Reactive oxygen species and angiotensin II signaling in vascular cells: implications in cardiovascular disease BJMBR Touyz,R.M.. Diseases such as hypertension, atherosclerosis, hyperlipidemia, and diabetes are associated with vascular functional and structural changes including endothelial dysfunction, altered contractility and vascular remodeling. Cellular events underlying these processes involve changes in vascular smooth muscle cell (VSMC) growth, apoptosis/anoikis, cell migration, inflammation, and fibrosis. Many factors influence cellular changes, of which angiotensin II (Ang II) appears to be amongst the most important. The physiological and pathophysiological actions of Ang II are mediated primarily via the Ang II type 1 receptor. Growing evidence indicates that Ang II induces its pleiotropic vascular effects through NADPH-driven generation of reactive oxygen species (ROS).... Tipo: Info:eu-repo/semantics/article Palavras-chave: Vascular smooth muscle cells; Remodeling; Inflammation; Signal transduction; Reactive oxygen species. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800018 Impact of the tissue factor pathway inhibitor gene on apoptosis in human vascular smooth muscle cells Genet. Mol. Biol. Dong,Xia; Song,Li-ping; Zhu,Dun-wan; Zhang,Hai-ling; Liu,Lan-xia; Leng,Xi-gang. Tissue factor pathway inhibitor (TFPI) plays a vitally important role in the blood coagulation pathway. Recent studies indicated that TFPI induces apoptosis in vascular smooth-muscle cells (VSMCs) in animals. The present study investigated whether the TFPI gene could also induce apoptosis in human vascular smooth-muscle cells (hVSMCs). Such cells were isolated from human umbilical arteries and subsequently transfected with pIRES-TFPI plasmid (2 μg/mL). MTT assaying and cell counting were applied to measure cell viability and proliferation, RT-PCR was utilized to analyze TFPI gene expression in the cells. Apoptosis was analyzed by fluorescence activated cell sorting (FACS). Several key proteins involved in apoptosis were examined through Western blotting.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Tissue factor pathway inhibitor; Vascular smooth muscle cells; Apoptosis. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100005 Registros recuperados: 3 Primeira ... 1 ... Última

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