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	Provedor de dados BJMBR (3) Autor Bendhack,L.M. (2) Araújo,A.V. (1) Lunardi,C.N. (1) Marshall,J.M. (1) Paulo,M. (1) Pereira,A.C. (1) Rodrigues,G.J. (1) da Silva,R.S. (1) Mais... Palavra-chave Vasodilatation (3) Ruthenium complex (2) Adenosine (1) Chemoreceptors (1) Conduit vessel (1) Hypoxia (1) NO-synthase (1) Nitric oxide (1) Nitric oxide donor (1) Nitrovasodilator (1) Noradrenaline (1) Resistance artery (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2011 (1) 2009 (1) 1998 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Nitric oxide synthesis and biological functions of nitric oxide released from ruthenium compounds BJMBR Pereira,A.C.; Paulo,M.; Araújo,A.V.; Rodrigues,G.J.; Bendhack,L.M.. During three decades, an enormous number of studies have demonstrated the critical role of nitric oxide (NO) as a second messenger engaged in the activation of many systems including vascular smooth muscle relaxation. The underlying cellular mechanisms involved in vasodilatation are essentially due to soluble guanylyl-cyclase (sGC) modulation in the cytoplasm of vascular smooth cells. sGC activation culminates in cyclic GMP (cGMP) production, which in turn leads to protein kinase G (PKG) activation. NO binds to the sGC heme moiety, thereby activating this enzyme. Activation of the NO-sGC-cGMP-PKG pathway entails Ca2+ signaling reduction and vasodilatation. Endothelium dysfunction leads to decreased production or bioavailability of endogenous NO that could... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Vasodilatation; Ruthenium complex; NO-synthase; Resistance artery; Conduit vessel. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900017 New nitric oxide donors based on ruthenium complexes BJMBR Lunardi,C.N.; da Silva,R.S.; Bendhack,L.M.. Nitric oxide (NO) donors produce NO-related activity when applied to biological systems. Among its diverse functions, NO has been implicated in vascular smooth muscle relaxation. Despite the great importance of NO in biological systems, its pharmacological and physiological studies have been limited due to its high reactivity and short half-life. In this review we will focus on our recent investigations of nitrosyl ruthenium complexes as NO-delivery agents and their effects on vascular smooth muscle cell relaxation. The high affinity of ruthenium for NO is a marked feature of its chemistry. The main signaling pathway responsible for the vascular relaxation induced by NO involves the activation of soluble guanylyl-cyclase, with subsequent accumulation of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide donor; Ruthenium complex; Nitrovasodilator; Vasodilatation. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100013 Chemoreceptors and cardiovascular control in acute and chronic systemic hypoxia BJMBR Marshall,J.M.. This review describes the ways in which the primary bradycardia and peripheral vasoconstriction evoked by selective stimulation of peripheral chemoreceptors can be modified by the secondary effects of a chemoreceptor-induced increase in ventilation. The evidence that strong stimulation of peripheral chemoreceptors can evoke the behavioural and cardiovascular components of the alerting or defence response which is characteristically evoked by novel or noxious stimuli is considered. The functional significance of all these influences in systemic hypoxia is then discussed with emphasis on the fact that these reflex changes can be overcome by the local effects of hypoxia: central neural hypoxia depresses ventilation, hypoxia acting on the heart causes... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypoxia; Adenosine; Chemoreceptors; Vasodilatation; Noradrenaline. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700002 Registros recuperados: 3 Primeira ... 1 ... Última

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