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	Provedor de dados Anais da ABC (AABC) (1) BJMBR (1) Autor CARLI,RAQUEL JACONI DE (1) CIDREIRA,THAINA (1) DANIELSKI,LUCINÉIA G. (1) DENICOL,TAIS (1) GIUSTINA,AMANDA D. (1) GOLDIM,MARIANA P.S. (1) JOAQUIM,LARISSA (1) Knöckel,J. (1) METZKER,KIUANNE L.L. (1) Müller,I.B. (1) NOVOCHADLO,MICHELE M. (1) PETRONILHO,FABRICIA (1) VIEIRA,THAYNAN (1) Walter,R.D. (1) Wrenger,C. (1) Mais... Palavra-chave Vitamin B6 (2) Antioxidant (1) Apicomplexa (1) Malaria (1) Oxidative stress (1) Pyridoxal phosphate synthase (1) Sepsis (1) Vitamin B1 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Vitamin B6 reduces oxidative stress in lungs and liver in experimental sepsis Anais da ABC (AABC) GIUSTINA,AMANDA D.; DANIELSKI,LUCINÉIA G.; NOVOCHADLO,MICHELE M.; GOLDIM,MARIANA P.S.; JOAQUIM,LARISSA; METZKER,KIUANNE L.L.; CARLI,RAQUEL JACONI DE; DENICOL,TAIS; CIDREIRA,THAINA; VIEIRA,THAYNAN; PETRONILHO,FABRICIA. Abstract Abstract: Sepsis is a life-threatening organ dysfunction induced by a disrupted host response to infecting pathogens. Inflammation and oxidative stress are intrinsically related to sepsis progression and organ failure. Vitamin B6 is an important cellular cofactor for metabolic processes and has anti-inflammatory and antioxidant properties. We aimed at evaluating the effect of vit B6 on inflammation and oxidative stress markers in the liver and lung of rats subjected to a relevant animal model of polymicrobial sepsis. Adult male Wistar rats were submitted to cecal ligation and perforation model and immediately after sepsis induction, vit B6 was administered as a single dose (600 mg/kg, subcutaneous). Twenty-four hours later, the lung and liver... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sepsis; Vitamin B6; Oxidative stress; Antioxidant. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000700627 Vitamin B1 and B6 in the malaria parasite: requisite or dispensable? BJMBR Wrenger,C.; Knöckel,J.; Walter,R.D.; Müller,I.B.. Vitamins are essential compounds mainly involved in acting as enzyme co-factors or in response to oxidative stress. In the last two years it became apparent that apicomplexan parasites are able to generate B vitamers such as vitamin B1 and B6 de novo. The biosynthesis pathways responsible for vitamin generation are considered as drug targets, since both provide a high degree of selectivity due to their absence in the human host. This report updates the current knowledge about vitamin B1 and B6 biosynthesis in malaria and other apicomplexan parasites. Owing to the urgent need for novel antimalarials, the significance of the biosynthesis and salvage of these vitamins is critically discussed in terms of parasite survival and their exploitation for drug... Tipo: Info:eu-repo/semantics/article Palavras-chave: Malaria; Apicomplexa; Pyridoxal phosphate synthase; Vitamin B6; Vitamin B1. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200001 Registros recuperados: 2 Primeira ... 1 ... Última

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