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| Matsumoto,Akiko; Arisaka,Hirofumi; Hosokawa,Yuki; Sakuraba,Shigeki; Sugita,Takeo; Umezawa,Nobuo; Kaku,Yuki; Yoshida,Kazu-ichi; Kuwana,Shun-ichi. |
| BACKGROUND: The antiepileptic drugs carbamazepine and gabapentin are effective in treating neuropathic pain and trigeminal neuralgia. In the present study, to analyze the effects of carbamazepine and gabapentin on neuronal excitation in the spinal trigeminal subnucleus caudalis (Sp5c) in the medulla oblongata, we recorded temporal changes in nociceptive afferent activity in the Sp5c of trigeminal nerve-attached brainstem slices of neonatal rats using a voltage-sensitive dye imaging technique. RESULTS: Electrical stimulation of the trigeminal nerve rootlet evoked changes in the fluorescence intensity of dye in the Sp5c. The optical signals were composed of two phases, a fast component with a sharp peak followed by a long-lasting component with a period of... |
| Tipo: Journal article |
Palavras-chave: Carbamazepine; Gabapentin; Rat brainstem; Spinal trigeminal nucleus; Voltage-sensitive dye imaging. |
| Ano: 2015 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100036 |
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