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	Provedor de dados Genet. Mol. Biol. (1) Autor Bandinelli,Eliane (1) Roisenberg,Israel (1) Simon,Daniel (1) Palavra-chave Genetics (1) Promoter polymorphisms (1) Von Willebrand disease (1) Von Willebrand factor (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2003 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Polymorphism in the promoter region of von Willebrand factor gene and von Willebrand disease type 1 Genet. Mol. Biol. Simon,Daniel; Bandinelli,Eliane; Roisenberg,Israel. The -1185A/G polymorphism in the 5'-regulatory region of the von Willebrand factor (VWF) gene was associated with VWF plasma levels in a normal population. This study was undertaken to evaluate whether there is a relationship between this polymorphism and type 1 von Willebrand disease (VWD), a disorder characterized by a quantitative deficiency of VWF. The association between this polymorphism and plasma VWF levels in normal Brazilian individuals was also analyzed. Control subjects (n = 460) and type 1 VWD patients (n = 41) were studied. Polymerase chain reaction (PCR) amplification of the 864-bp VWF promoter region followed by AccII restriction-digestion was used to identify the -1185A/G genotypes. The -1185G allele frequency was 57% in normal individuals... Tipo: Info:eu-repo/semantics/article Palavras-chave: Von Willebrand factor; Promoter polymorphisms; Genetics; Von Willebrand disease. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572003000400001 Registros recuperados: 1 Primeira ... 1 ... Última

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