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	Provedor de dados BABT (1) Autor Geyikoglu,Fatime (1) Türkez,Hasan (1) Palavra-chave Aflatoxin B1 (1) Genotoxicity (1) Selenium (1) Sister-chromatid exchanges (1) Whole blood cultures (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2006 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Protective effect of sodium selenite against the genotoxicity of aflatoxin B1 in human whole blood cultures BABT Geyikoglu,Fatime; Türkez,Hasan. This study was designed to investigate the effects of selenium and aflatoxin on human whole blood cultures (WBC) in relation to induction of sister-chromatid exchange (SCE). The results showed that the frequency of SCEs in peripheral lymphocytes was significantly increased by the direct-acting mutagen AFB1 (at doses 5 and 10 µM except for 1µM) compared to controls. When sodium selenite (Na2SeO3) was added alone at a molar ratio of 5x10-7 and 1x10-6, cells did not show significant increase in SCE frequency. Whereas, SCE rates induced by the various AFB1 concentrations could be significantly reduced by the presence of Na2SeO3 in a clear dose-related manner. These results indicated that selenite and AFB1 mutually antagonized their ability to cause DNA damage... Tipo: Info:eu-repo/semantics/article Palavras-chave: Aflatoxin B1; Selenium; Sister-chromatid exchanges; Genotoxicity; Whole blood cultures. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132006000400006 Registros recuperados: 1 Primeira ... 1 ... Última

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