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	Provedor de dados 74 (3) Autor Graf,Ulrich (3) Spanó,Mário A. (2) Antunes,Lusânia M.G. (1) Guterres,Zaira R. (1) Kerr,Warwick E. (1) Pereira,Denise G. (1) Rezende,Alexandre A.A. de (1) Silva,Regildo M.G. da (1) Silva,Regildo Márcio Gonçalves da (1) Sousa,Neila C. de (1) Sousa,Neila Coelho de (1) Spanó,Mário Antônio (1) Mais... Palavra-chave Wing spot test (3) Antigenotoxicity (2) SMART (2) Genotoxicity (1) Genotoxicity tests (1) Micronucleus assay (1) Somatic mutation and recombination test - SMART (1) Synergistic effect (1) Toxicity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2009 (1) 2008 (2) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster 74 Silva,Regildo Márcio Gonçalves da; Sousa,Neila Coelho de; Graf,Ulrich; Spanó,Mário Antônio. A Mandevilla velutina crude extract was investigated using the mouse micronucleus test (MNT) and the Drosophila melanogaster somatic mutation and recombination test (SMART) using standard (ST) and high bioactivation (HB) crosses. The MNT used 10 mg, 20 mg or 40 mg per 100 g of body weight (bw) of extract with and without 0.2 mg per 100 g bw peritoneal cyclophosphamide. There was no genotoxicity in the negative control or extract only groups and, compared to the cyclophosphamide control, there was a significant reduction in micronucleated polychromatic erythrocytes in all the groups given extract plus cyclophosphamide. For SMART larvae were fed 5 or 10 mg mL-1 of extract for seven days with and without 0.89 mg mL-1 of urethane given on day seven. The ST and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antigenotoxicity; Genotoxicity tests; Micronucleus assay; SMART; Wing spot test. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400023 Modulatory effects of Tabebuia impetiginosa (Lamiales, Bignoniaceae) on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster 74 Sousa,Neila C. de; Rezende,Alexandre A.A. de; Silva,Regildo M.G. da; Guterres,Zaira R.; Graf,Ulrich; Kerr,Warwick E.; Spanó,Mário A.. The wing Somatic Mutation and Recombination Test (SMART) in D. melanogaster was used to study genotoxicity of the medicinal plant Tabebuia impetiginosa. Lapachol (naphthoquinone) and β-lapachone (quinone) are the two main chemical constituents of T. impetiginosa. These compounds have several biological properties. They induce apoptosis by generating oxygen-reactive species, thereby inhibiting topoisomerases (I and II) or inducing other enzymes dependent on NAD(P)H:quinone oxidoreductase 1, thus affecting cell cycle checkpoints. The SMART was used in the standard (ST) version, which has normal levels of cytochrome P450 (CYP) enzymes, to check the direct action of this compound, and in the high bioactivation (HB) version, which has a high constitutive level... Tipo: Info:eu-repo/semantics/article Palavras-chave: Genotoxicity; Synergistic effect; Somatic mutation and recombination test - SMART; Toxicity; Wing spot test. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000200027 Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster 74 Pereira,Denise G.; Antunes,Lusânia M.G.; Graf,Ulrich; Spanó,Mário A.. Panax ginseng is one of the most widely prescribed herbal medicines for the treatment of cancer, diabetes, chronic inflammation, and neurodegenerative and cardiovascular diseases. Since the use of alternative medicines in combination with conventional therapy may increase the risk of unwanted interactions, we investigated the possible genotoxicity of a water-soluble form of the dry root of P. ginseng (2.5, 5.0 or 10.0 mg/mL) and its ability to protect against the genotoxicity of doxorubicin (DOX; 0.125 mg/mL) by using the Drosophila melanogaster wing somatic mutation and recombination test (SMART) with standard and high-bioactivation crosses of flies. Panax ginseng was not genotoxic at the concentrations tested, whereas DOX-induced genotoxicity in... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antigenotoxicity; SMART; Wing spot test. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000500024 Registros recuperados: 3 Primeira ... 1 ... Última

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