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| Registros recuperados: 22 | |
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| Lemos,Odilon A.; Sanches,Júlio C.M.; Silva,Ícaro E.F.; Silva,Márcio L.A.; Vinhólis,Adriana H.C.; Felix,Mireille A.P.; Santos,Raquel A.; Cecchi,Andréa O.. |
| Tabebuia sp. is native to tropical rain forests throughout Central and South America. Although the biological and pharmacological effects of bark extracts have been intensely studied, little is known on the extract obtained from the flower. Herein, the genotoxic potential of a flower extract from T. impetiginosa ("ipê roxo") on the blood and liver cells of Wistar rats was evaluated. Experimental procedures involved only male animals. Graduated concentrations of the extract, viz., 100, 300 and 500 mg kg-1 of body weight, were gavage-administered and 24 h latter cells were collected and processed for analysis. With the exception of the 100 mg kg-1 dose, a significant increase in DNA damage was noted, when compared with a negative control group. Although the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tabebuia impetiginosa; Comet assay; Wistar rats; Natural compounds. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300017 |
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| Serrano-Gallardo,Luis B; Soto-Domínguez,Adolfo; Ruiz-Flores,Pablo; Nava-Hernández,Martha P; Morán-Martínez,Javier; García-Garza,Rubén; Martínez-Pérez,Edith F. |
| A Ruta graveolens se le atribuyen propiedades benéficas en medicina tradicional, sin embargo se ha demostrado que también puede producir efectos adversos. A la fecha no existe evidencia que ratifique que R. graveolens es totalmente inofensiva, por este motivo el objetivo de este estudio fue determinar el efecto tóxico del extracto acuoso de las hojas de esta especie vegetal en hígado de rata. Se utilizaron 25 ratas Wistar y se dividieron en 5 grupos (n=5). El grupo 1 correspondió al grupo control negativo, el grupo 2 o control positivo se trató con 100 mg de dexametasona/kg/día. Los grupos 3 y 4 se trataron con 30 y 100 mg de extracto de R. graveolens respectivamente. Al grupo 5 se le administraron 100 mg de dexametasona/kg/día combinado con 100 mg de... |
| Tipo: Journal article |
Palavras-chave: Ruta graveolens; Extracto acuoso; Toxicidad hepática; Ratas Wistar; Ruta graveolens; Aqueous extract; Liver toxicity; Wistar rats. |
| Ano: 2013 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300043 |
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| Oyeyemi,Matthew Olugbenga; Adeniji,Deborah Adejoke. |
| The morphological characteristics and haematological studies were studied in fifteen male albino rats (Wistar Strain) aged between 12 and 14 weeks and with a body weight of 150- 180g. The rats were allowed to feed on commercially prepared rat pellet and provided with fresh water ad libitum. The rats were divided into three groups; the rats were in groups A, B and C of 5 rats each. Group A served as control of the study; Group B was treated with Chloramphenicol at the dose rate of 25mg/kg body weight per os for 20 days; while Group C was treated for 25 days. Semen used in this study was obtained from the caudal epididymides while morphological aberrations were determined from spermatozoa counted after stained with Wells and Awa stain. Results of the... |
| Tipo: Journal article |
Palavras-chave: Chloramphenicol; Breeding; Spermatozoa; Wistar rats; Infertility. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100001 |
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| Pedrazzi,Vinícius; Del Ciampo,José Orestes; do Nascimento,Cássio; Issa,João Paulo Mardegan. |
| The aim of this study was to evaluate some biological characteristics and toxicity of basic formulations of dentifrices containing such substances, and to compare them with two existing products in market which also contains silic in their formulations. In this way, it was evaluated some biological parameters: weight of the animals, oral toxicity, hematological parameters, urinary analysis, and histological evaluation. The thrombocytes were also statistically at normal levels. The glutamate-pyruvate transaminase (TGP) showed normal aspect in 5 of the tested groups, as in control. Meanwhile, the oxalacetic transaminase (AST) in one group had a small increase in the control group. Regarding urine, in exception the rats of one group, the rats of the 4 other... |
| Tipo: Journal article |
Palavras-chave: Silica; Dentifrices; Histology; Wistar rats. |
| Ano: 2009 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100028 |
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| Silva Junior,Valdemiro Amaro da; Lins Amorim,Marleyne José Afonso Accioly; Amorim Junior,Adelmar Afonso de; Pinto,Catarina Ferreira; Deiró,Tereza B. J.; Oliveira,João Ricardo M. de; Peixoto,Christina Alves; Manhães-de-Castro,Raul. |
| The aim of the present study was to test the hypothesis that the application of fluoxetine a highly selective serotonin reuptake inhibitor (SSRI) in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses of fluoxetine 24 hours after birth. Each litter stayed with its respective mother during 21 days. Body weight (BW) was measured daily from the 1st -21st day to calculate daily doses of fluoxetine. 5 mg (T1), 10 mg (T2) 20 mg (T3) or deionized water, were injected intraperitoneally. On the 21st day, animals were heparinized, anesthetized and blood was collected by cardiac puncture to determine by radioimmunoassay the follicle stimulating hormone (FSH) levels.... |
| Tipo: Journal article |
Palavras-chave: Fluoxetine; Testis development; Sertoli cells; Wistar rats. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100009 |
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| FACCIO,LUCIANA; SILVA,ALEKSANDRO S. DA; TONIN,ALEXANDRE A.; OBERHERR,LUCAS; GRESSLER,LUCAS T.; OLIVEIRA,CAMILA B.; OLIVEIRA,DIONATAN T.; SANGOI,MANUELA B.; MORESCO,RAFAEL N.; SAMARA,YASMIN N.; VEIGA,MARCELO; DUARTE,MARTA M.M.F.; MONTEIRO,SILVIA G.. |
| The aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Protozoa; Wistar rats; Testicular lesion; Reproduction; Oxidative stress. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537 |
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| MOLZ,PATRÍCIA; ELLWANGER,JOEL H.; ZENKNER,FERNANDA F.; CAMPOS,DEIVIS DE; PRÁ,DANIEL; PUTZKE,MARISA T.L.; FRANKE,SILVIA I.R.. |
| ABSTRACT This study evaluated the recognition memory and the levels of DNA damage (blood and hippocampus) in undernourished young Wistar rats. The experiment was conducted along 14-week with rodents divided in control group (CG, n=8) and undernourished group (UG, n=12) which was submitted to caloric restriction. Nutritional status for undernutrition was defined by Body Mass Index (BMI) ≤0.45g/cm2 and by weighting the organs/tissue (liver, spleen, intestine, peritoneal fat, kidney and encephalon). The Novel Object Recognition Test assessed recognition memory and the Comet Assay evaluated the levels of DNA damage. Student t test, 2-way ANOVA and Pearson's correlation analysis were used and the significance level was of p<0.05. The UG showed lower BMI and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: DNA damage; Memory; Nutritional status; Undernutrition; Wistar rats. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501863 |
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| SGROTT,SANDRO M.; NEVES,RODRIGO D.; D’ACAMPORA,ARMANDO J.; BERNARDES,GERALDO J.S.; BELMONTE,LUIZ; MARTINS,THIAGO C.; BOBINSKI,FRANCIANE; CARGNIN-FERREIRA,EDUARDO; HOEPERS,ANDREZA; COMIM,CLARISSA M.; MARTINS,DANIEL F.; PIOVEZAN,ANNA P.. |
| Abstract Silicone breast implant is associated with complications inherent to the surgical procedure. Prosthesis coating with polyurethane, however, commonly reduces the incidence of such complications. In this paper, the authors evaluated the inflammatory histomorphometric profile and oxidative damage associated to the implant of polyester urethane sheets. Forty-eight Wistar rats were divided into Sham or polyester urethane groups (n = 8/group) and underwent a polyester urethane implant in the dorsal skinfold. Tissue samples were collected on days seven, 30, and 90 after surgery and subjected to histomorphometric analysis and biochemical tests. Results were analyzed by one-way ANOVA (p ≤ 0.05). Peri-implant tissue samples exhibited characteristic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Polyurethane; Inflammation; Cytokines; Oxidative stress; Wistar rats. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502211 |
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| Andrade,Bruno Horta; Chaves,Miriam Martins; Ribeiro,Angela Maria. |
| A study was conducted to compare health status of male adult Wistar rats from two Experimental Animal Houses of UFMG with literature data of SPF (free from specific pathogens) and conventional rats. The animals were divided into two groups: Group I (n=10), rats from the experimental animal houses of FAFICH and Group II (n=10) from ICB and following aspects were studied: a) evident clinical signs (behavior modification, hair loss (alopecia), b) leukocyte counts, c) feces exam and d) histological study of the lungs. The rats did not show clinical signs. However, when compared with SPF and conventional rats, both the groups showed a significant increase (p<0,05) of leukocyte count. On feces exam we detected some parasites and on lung histological exam we... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Wistar rats; Animal houses; Cellular count. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000300006 |
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| Guimarães,Fernando; Schanoski,Alessandra Soares; Cavalcanti,Tereza Cristina Samico; Juliano,Priscila Bianchi; Viera-Matos,Ana Neuza; Rettori,Ovídio. |
| The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tumor growth rate; Spontaneous tumor regression; Wistar rats; Walker 256. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014 |
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| Campos,K.E.; Volpato,G.T.; Calderon,I.M.P.; Rudge,M.V.C.; Damasceno,D.C.. |
| The aim of the present study was to assess the reproductive parameters of obese Wistar rats and to determine the frequency of their obese adult offspring. Neonatal rats were divided into two groups: F1 generation, induced to obesity by monosodium glutamate (MSG; F1MSG, N = 30), and rats given saline (F1CON, N = 13). At 90 days of age all animals were mated, producing the F2 offspring (F2CON, N = 28; F2MSG, N = 15). Reproductive parameters (fertility, pregnancy, and delivery indexes) were evaluated in F1 rats. F2 newborns were weighed, and the obesity parameter for F1 and F2 generations was determined from months 5 to 7 of life. At month 7, periovarian fat was weighed and no differences were found. Mean newborn weight also did not differ. The F1 and F2MSG... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Obesity; Offspring; Fertility; Wistar rats; Monosodium glutamate; Transgeneration. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200008 |
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| Câmara,C.C.; Oriá,R.B.; Felismino,T.C.; Silva,A.P. da; Silva,M.A.M. da; Alcântara,J.V.A.; Costa,S.B.C.; Vicente,A.C.P.; Teixeira-Santos,T.J.; Castro-Costa,C.M. de. |
| The objective of the present study was to describe motor behavioral changes in association with histopathological and hematological findings in Wistar rats inoculated intravenously with human T-cell lymphotropic virus type 1 (HTLV-1)-infected MT2 cells. Twenty-five 4-month-old male rats were inoculated with HTLV-1-infected MT2 cells and 13 control rats were inoculated with normal human lymphocytes. The behavior of the rats was observed before and 5, 10, 15, and 20 months after inoculation during a 30-min/rat testing time for 5 consecutive days. During each of 4 periods, a subset of rats was randomly chosen to be sacrificed in order to harvest the spinal cord for histopathological analysis and to obtain blood for serological and molecular studies.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Motor behaviors; HTLV-1-infected MT2 cells; Wistar rats; Experimental myelopathy. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700008 |
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| Barbosa,C.R.; Albuquerque,E.M.V.; Faria,E.C.; Oliveira,H.C.F.; Castilho,L.N.. |
| The metabolic effects of carbohydrate supplementation in mice have not been extensively studied. In rats, glucose- and fructose-rich diets induce hypertriacylglycerolemia. In the present study, we compared the metabolic responses to two monosaccharide supplementations in two murine models. Adult male Wistar rats (N = 80) and C57BL/6 mice (N = 60), after 3 weeks on a standardized diet, were submitted to dietary supplementation by gavage with glucose (G) or fructose (F) solutions (500 g/L), 8 g/kg body weight for 21 days. Glycemia was significantly higher in rats after fructose treatment (F: 7.9 vs 9.3 mM) and in mice (G: 6.5 vs 10 and F: 6.6 vs 8.9 mM) after both carbohydrate treatments. Triacylglycerolemia increased significantly 1.5 times in rats after G... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Glucose or fructose supplementation; Triacylglycerolemia; Insulin resistance; C57BL/6 mice; Wistar rats. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300007 |
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| Blatt,S.L.; Takahashi,R.N.. |
| In order to examine the relationship between anxiety and reinforcing effects of alcohol, drug-naive male Wistar rats weighing 250-300 g were classified as "anxious" and "non-anxious" in the elevated plus-maze test. A conditioned place preference test was then used to investigate the reinforcing effects of ethanol (EtOH) on these animals. On 2 alternate days, groups of "anxious", "non-anxious" and "normal" rats received intraperitoneal (ip) injections of EtOH (0.5, 1.0 or 1.5 g/kg) immediately before a 15-min confinement to the white compartment. On the 2 intervening days the same rats received ip injections of saline before confinement to the opposite compartment. On day 5, a 15-min free-choice test was carried out with no injections. Rats classified as... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anxiety; Plus-maze; Place preference; Ethanol; Wistar rats. |
| Ano: 1999 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400013 |
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| Molena-Fernandes,C.; Bersani-Amado,C. A.; Ferraro,Z. M.; Hintze,L. J.; Nardo Jr.,N.; Cuman,R. K. N.. |
| We aimed to evaluate the effects of aerobic exercise training (4 days) and metformin exposure on acute glucose intolerance after dexamethasone treatment in rats. Forty-two adult male Wistar rats (8 weeks old) were divided randomly into four groups: sedentary control (SCT), sedentary dexamethasone-treated (SDX), training dexamethasone-treated (DPE), and dexamethasone and metformin treated group (DMT). Glucose tolerance tests and in situ liver perfusion were undertaken on fasting rats to obtain glucose profiles. The DPE group displayed a significant decrease in glucose values compared with the SDX group. Average glucose levels in the DPE group did not differ from those of the DMT group, so we suggest that exercise training corrects dexamethasone-induced... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Exercise; Glucose intolerance; Dexamethasone; Wistar rats; Diabetes mellitus; Prevention and control. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201101 |
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| Registros recuperados: 22 | |
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