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	Provedor de dados BJMBR (2) Autor Cai,Shanglang (1) Dai,Hongyan (1) Deng,Liehua (1) Fang,Ruihua (1) Guan,Jun (1) Li,Jingrong (1) Qin,Qiaoji (1) Wang,Jianqin (1) Zhang,Xuezhi (1) Zhou,Changyong (1) Mais... Palavra-chave Wnt/β-catenin pathway (2) Emodin (1) Hypoxia injury (1) Malignant melanoma (1) Metastasis (1) MiR-138 (1) Myocardial infarction (1) NOP14 (1) Proliferation (1) Sirt1/AKT pathway (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Emodin protects H9c2 cells from hypoxia-induced injury by up-regulating miR-138 expression BJMBR Zhang,Xuezhi; Qin,Qiaoji; Dai,Hongyan; Cai,Shanglang; Zhou,Changyong; Guan,Jun. Myocardial infarction (MI) is a common presentation for ischemic heart disease, which is a leading cause of death. Emodin is a Chinese herbal anthraquinone used in several diseases. However, the effect of emodin in hypoxia-induced injury in cardiomyocytes has not been clearly elucidated. Our study aimed to clarify the functions of emodin in hypoxia-induced injury in rat cardiomyocytes H9c2 and explore the underlying mechanism. The effects of emodin on cell viability and apoptosis were analyzed by the Cell counting kit-8 assay and flow cytometry assay, respectively. The cell proliferation- and cell apoptosis-related proteins were detected by western blot. qRT-PCR was used to determine the relative expression of miR-138. Cell transfection was performed to... Tipo: Info:eu-repo/semantics/article Palavras-chave: Emodin; Myocardial infarction; Hypoxia injury; MiR-138; Sirt1/AKT pathway; Wnt/β-catenin pathway. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000300603 NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway BJMBR Li,Jingrong; Fang,Ruihua; Wang,Jianqin; Deng,Liehua. Malignant melanoma is an aggressive skin cancer with a high mortality rate. Nucleolar protein 14 (NOP14) has been implicated in cancer development. However, the role of NOP14 in malignant melanoma progression remains largely unclear. In this study, we observed that malignant melanoma tissue showed NOP14 down-regulation compared to melanocytic nevi tissues. Moreover, we observed that NOP14 expression was significantly associated with melanoma tumor thickness and lymph node metastasis. NOP14 overexpression in melanoma cells suppressed proliferation, caused G1 phase arrest, promoted apoptosis, and inhibited melanoma cell migration and invasion. Further investigations revealed that NOP14 overexpression reduced the expression levels of Wnt3a, β-catenin, and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Malignant melanoma; Metastasis; NOP14; Proliferation; Wnt/β-catenin pathway. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100604 Registros recuperados: 2 Primeira ... 1 ... Última

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