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Mucoadhesive drug delivery systems 60
Carvalho,Flávia Chiva; Bruschi,Marcos Luciano; Evangelista,Raul Cesar; Gremião,Maria Palmira Daflon.
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mucoadhesion; Bioadhesion; Mucoadhesive systems; Drugs/delivery.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100002
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Evaluation of Cedrela gum as a binder and bioadhesive component in ibuprofen tablet formulations 60
Odeniyi,Michael Ayodele; Babalola,Adepeju Oluwadamilare; Ayorinde,John Oluwasogo.
The compressional, mechanical and bioadhesive properties of tablet formulations incorporating a new gum obtained from the incised trunk of the Cedrela odorata tree were evaluated and compared with those containing hydroxypropylmethylcellulose (HPMC). Compressional properties were evaluated using Hausner's ratio, Carr's Index, the angle of repose, and Heckel, Kawakita and Gurnham plots. Ibuprofen tablets were prepared using the wet granulation method. Bioadhesive studies were carried out using the rotating cylinder method in either phosphate buffer pH 6.8 or 0.1 M hydrochloric acid media. The gum is a low viscosity polymer (48 cPs), and Fourier transform infrared spectroscopy revealed the presence of a hydroxyl group. Py and Pk values, which are measures of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cedrela gum/evaluation; Cedrela gum/compression properties; Cedrela gum/bioadhesive component; Tablet formulations; Hydroxypropylmethylcellulose; Ibuprofen tablets/bioadhesive studies; Bioadhesion.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100011
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Formulation and evaluation of buccoadhesive quetiapine fumarate tablets 60
Potu,Appa Rao; Pujari,Naresh; Burra,Shashidher; Veerareddy,Prabhakar Reddy.
The aim of present study was to develop and evaluate buccoadhesive Quetiapine Fumarate (QF) tablets, which is extensively metabolised by liver. Buccoadhesive tablets of QF were prepared using HPMC K4M, HPMC K15M and combination of carbopol and HPC as mucoadhesive polymers by direct compression method. Sodium deoxycholate was added to formulation to improve the permeation of drug. The formulations were tested for bioadhesion strength, ex vivo residence time, swelling time and in vitro dissolution studies and ex vivo permeation studies. Optimized formulation (F3) showed 92% in vitro release in 8 h and 67% permeation of drug through porcine buccal mucosa and followed fickian release mechanism with zero order kinetics. FTIR studies of optimized formulation...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Quetiapine Fumarate; Bioadhesion; In vivo mucoadhesive behaviour.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200017
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