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Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells ArchiMer
Hughes, Kristelle; Ho, Raimana; Greff, Stéphane; Filaire, Edith; Ranouille, Edwige; Chazaud, Claire; Herbette, Gaëtan; Butaud, Jean-françois; Berthon, Jean-yves; Raharivelomanana, Phila.
Hair loss is becoming increasingly prevalent as dietary and living habits change. The search for natural products to limit hair loss has led to tapping into traditional cosmetic knowledge. We studied three plants of the Polynesian cosmetopoeia, Bidens pilosa, Calophyllum inophyllum and Fagraea berteroana, to determine their ability to promote hair growth. Their chemical content was characterized by liquid chromatography coupled to mass spectrometry (LC-MS). Their proliferative activity on dermal papilla cells (DPCs) was assessed via MTT assay and molecular targets were evaluated by RT-qPCR analysis of seven factors involved in the modulation of the hair cycle, CCND1, LEF1, DKK1, WNT5A PPARD, TGFΒ1, PPARD and RSPO2. Our results show that our extracts...
Tipo: Text Palavras-chave: Polynesian plants; Ethnobotany; Cosmetopoeia; Dermal papilla; Hair growth; Wnt.
Ano: 2020 URL:
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