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Collares,E.F.; Troncon,L.E.A.. |
Dipyrone (metamizole), acting through its main metabolites 4-methyl-amino-antipyrine and 4-amino-antipyrine, has established analgesic, antipyretic, and spasmolytic pharmacological effects, which are mediated by poorly known mechanisms. In rats, intravenously administered dipyrone delays gastric emptying (GE) of liquids with the participation of capsaicin-sensitive afferent fibers. This effect seems to be mediated by norepinephrine originating from the sympathetic nervous system but not from the superior celiac-mesenteric ganglion complex, which activates β2-adrenoceptors. In rats, in contrast to nonselective non-hormonal anti-inflammatory drugs, dipyrone protects the gastric mucosa attenuating the development of gastric ulcers induced by a number of... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dipyrone; Gastric emptying; Gastric mucosa; Sphincter of Oddi; Intestinal Motility; Adrenergic receptors. |
Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000200301 |
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Fregnani,José HumbertoTavares Guerreiro; Macea,José Rafael; Barros,Mirna Duarte; Liquidato,Bianca Maria; Macea,Maria Inez Marcondes; Alves,Adriana Leal; Pereira,Celina Siqueira Barbosa; Pinto,Antonio Cardoso; Carvalho,Maria de Fátima Pereira de; Carillo,Joáo. |
There is no consensus about the precise definition of what the cardia is. Although this term is often utilized in the medical literature, it takes on a variety of meanings, depending on the context. For histologists and endoscopists, the cardia is a region of the stomach immediately below the gastroesophageal junction. However, the concepts of gastroesophageal junction used by histologists and endoscopists are not the same as used by anatomists. This junction is histologically defined as the abrupt transition from the nonkeratinized stratified squamous epithelium of the esophagus to simple columnar epithelium and corresponds to the endoscopically defined Z-line. Nevertheless, this epithelial change does not occur exactly in the anatomical transition... |
Tipo: Journal article |
Palavras-chave: Cardia; Gastroesophageal junction; Lower esophageal sphincter; Gastric mucosa; Terminology. |
Ano: 2007 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200023 |
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