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CAVALCANTI,PAULO M.S.; MARTINS,MARIA DO CARMO C.; NUNES,PAULO H.M.; ALVES FILHO,FRANCISCO C.; SILVA,JANYERSON D.P.; CAVALCANTI,SUZANA M.G.. |
Abstract This study investigated the effects of the ethanolic extract from the bark of Combretum leprosum (ECL) on intestinal transit and castor-oil induced diarrhea in mice. The oral administration of ECL (750 and 1000 mg/kg) slowed intestinal transit (ID50 of 455 mg/kg). The ECL (250-1000 mg/kg) reduced castor-oil induced diarrhea, in a time- and dose-dependent manner (p < 0.05). To determine if antidiarrheal effect of ECL involves α2-adrenergic or opioid receptor activation, the mice were pretreated with antagonists of these receptors, yohimbine or naloxone respectively. None of these drugs inhibited the antidiarrheal effect of ECL. To test if antidiarrheal effect of ECL is due to an antisecretory action, we realized the enteropooling assay on rats.... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Combretum leprosum; Antidiarrheal effect; Medicinal plants; Polyphenols; Intestinal transit; Enteropooling. |
Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100701 |
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Graça,J.R.V; Macedo,G.M; Palheta Jr,R.C; Gondim,F. de A.A; Nogueira,R.O; Correia,J.M; Rola,F.H; Oliveira,R.B; Souza,M.A.N; Santos,A.A. |
Sildenafil slows down the gastric emptying of a liquid test meal in awake rats and inhibits the contractility of intestinal tissue strips. We studied the acute effects of sildenafil on in vivo intestinal transit in rats. Fasted, male albino rats (180-220 g, N = 44) were treated (0.2 mL, iv) with sildenafil (4 mg/kg) or vehicle (0.01 N HCl). Ten minutes later they were fed a liquid test meal (99m technetium-labeled saline) injected directly into the duodenum. Twenty, 30 or 40 min after feeding, the rats were killed and transit throughout the gastrointestinal tract was evaluated by progression of the radiotracer using the geometric center method. The effect of sildenafil on mean arterial pressure (MAP) was monitored in a separate group of rats (N = 14). Data... |
Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Intestinal transit; Mean arterial pressure; Scintigraphy; Sildenafil. |
Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100012 |
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