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Cytotoxicity and anti-Sporothrix brasiliensis activity of the Origanum majorana Linn. oil BJM
Waller,Stefanie Bressan; Madrid,Isabel Martins; Ferraz,Vanny; Picoli,Tony; Cleff,Marlete Brum; de Faria,Renata Osório; Meireles,Mário Carlos Araújo; de Mello,João Roberto Braga.
Abstract The study aimed to evaluate the anti-Sporothrix sp. activity of the essential oil of Origanum majorana Linn. (marjoram), its chemical analysis, and its cytotoxic activity. A total of 18 fungal isolates of Sporothrix brasiliensis (n: 17) from humans, dogs and cats, and a standard strain of Sporothrix schenckii (n: 1) were tested using the broth microdilution technique (Clinical and Laboratory Standard Institute - CLSI M27-A3) and the results were expressed in minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC). The MIC50 and MIC90 of itraconazole against S. brasiliensis were 2 µg/mL and 8 µg/mL, respectively, and the MFC50 and MFC90 were 2 µg/mL and >16 µg/mL, respectively, with three S. brasiliensis isolates...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sporotrichosis; Sporothrix schenckii complex; Antifungal resistance; Marjoram; Lamiaceae.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400896
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Essential oils of Cunila galioides and Origanum majorana as anesthetics for Rhamdia quelen: efficacy and effects on ventilation and ionoregulation Neotropical Ichthyology
Cunha,Jessyka A. da; Scheeren,Cecília Á.; Salbego,Joseânia; Gressler,Luciane T.; Madaloz,Laurício M.; Bandeira-Junior,Guerino; Bianchini,Adriane E.; Pinheiro,Carlos G.; Bordignon,Sérgio A. L.; Heinzmann,Berta M.; Baldisserotto,Bernardo.
ABSTRACT This study evaluated anesthetic efficacy and possible effects of the essential oils (EOs) of Cunila galioides (EOC) and Origanum majorana (EOO) on ventilatory rate (VR) and ionoregulation in Rhamdia quelen. In the anesthesia assessments, 50, 100, 200 and 300 μL L-1 EOC and 50, 100, 200, 300, 400 and 500 μL L-1 EOO were tested, and time for induction to sedation and anesthesia stages, as well as recovery, were taken. A second trial employed lower concentrations of both EOs, 10, 25, 50 and 100 μL L-1, in order to verify VR and Na+, K+ and Cl- whole body net fluxes. Sedation was achieved with both oils at 100 µL L-1, and anesthesia at ≥ 200 µL L-1. There was no significant difference between control and EO-treated groups regarding VR, but all fish...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ionoregulatory balance; Marjoram; Pennyroyal; Silver catfish; Ventilatory rate.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252017000100213
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