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| Xavier,João Lucas P.; Scomparin,Dionizia X.; Pontes,Catherine C.; Ribeiro,Paulo Roberto; Cordeiro,Maiara M.; Marcondes,Jessica A.; Mendonça,Felipe O.; Silva,Makcine T. da; Oliveira,Fabio B. de; Franco,Gilson C.N.; Grassiolli,Sabrina. |
| In the present study we analyzed morphological and metabolic alterations in dams nursing small litters and their consequences to offspring throughout lactation. Offspring sizes were adjusted to Small Litter (SL, 3 pups/ dam) and Normal Litter (NL, 9 pups/ dam). Body weight, food intake, white adipose tissue (WAT) content, histological analysis of the pancreas, mammary gland (MG) and brown adipose tissue (BAT) as well as, plasma parameters and milk composition were measured in dams and pups on the 7th, 14th and 21st days of lactation. In general, SL-dams presented higher body weight and retroperitoneal fat content, elevated fat infiltration in BAT, reduced islets size and hyperglycemia throughout lactation in relation to NL-dams (p<0.05). Moreover, MG... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Dams; Metabolic programming; Milk; Offspring. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100803 |
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| Da Costa,N. Meireles; Visoni,S.B.C.; Dos Santos,I.L.; Barja-Fidalgo,T.C.; Ribeiro-Pinto,L.F.. |
| Early nutrition plays a long-term role in the predisposition to chronic diseases and influences the metabolism of several drugs. This may happen through cytochromes P450 (CYPs) regulation, which are the main enzymes responsible for the metabolism of xenobiotics. Here, we analyzed the effects of maternal protein restriction (MPR) on the expression and activity of hepatic offspring’s CYPs during 90 days after birth, using Wistar rats as a mammal model. Hepatic CYP1A1, CYP1A2, CYP2B1, CYP2B2 and CYP2E1 mRNA and protein expression, and associated catalytic activities (ECOD, EROD, MROD, BROD, PROD and PNPH) were evaluated in 15-, 30-, 60-, and 90-day-old offspring from dams fed with either a 0% protein (MPR groups) or a standard diet (C groups) during the 10... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Maternal protein restriction; Offspring; CYP; Perinatal nutrition; Metabolic programming. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001100603 |
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