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	Provedor de dados BJMBR (2) Autor Abel,L.C.J. (1) Cunha-Neto,E. (1) Domínguez,M.C. (1) García-Vallejo,F. (1) Kalil,J. (1) Tamayo,O. (1) Mais... Palavra-chave Molecular mimicry (2) Cardiac myosin (1) Chagas' disease (1) Crossreactive T cells (1) HTLV-I (1) Retrovirus (1) TSP/HAM (1) Trypanosoma cruzi (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2005 (1) 1997 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin BJMBR Abel,L.C.J.; Kalil,J.; Cunha-Neto,E.. Previous reports from our group have demonstrated the association of molecular mimicry between cardiac myosin and the immunodominant Trypanosoma cruzi protein B13 with chronic Chagas' disease cardiomyopathy at both the antibody and heart-infiltrating T cell level. At the peripheral blood level, we observed no difference in primary proliferative responses to T. cruzi B13 protein between chronic Chagas' cardiopathy patients, asymptomatic chagasics and normal individuals. In the present study, we investigated whether T cells sensitized by T. cruzi B13 protein respond to cardiac myosin. T cell clones generated from a B13-stimulated T cell line obtained from peripheral blood of a B13-responsive normal donor were tested for proliferation against B13 protein and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Molecular mimicry; Crossreactive T cells; Cardiac myosin; Trypanosoma cruzi; Chagas' disease. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100007 Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy BJMBR García-Vallejo,F.; Domínguez,M.C.; Tamayo,O.. Viruses share antigenic sites with normal host cell components, a phenomenon known as molecular mimicry. It has long been suggested that viral infections might trigger an autoimmune response by several mechanisms including molecular mimicry. More than 600 antiviral monoclonal antibodies generated against 11 different viruses have been reported to react with 3.5% of cells specific for uninfected mouse organs. The main pathological feature of tropical spastic paraparesis/human T-lymphotropic virus type I (HTLV-I)-associated myelopathy (TSP/HAM) is a chronic inflammation of the spinal cord characterized by perivascular cuffing of mononuclear cells accompanied by parenchymal lymphocytic infiltration. We detected the presence of autoantibodies against a 98- to... Tipo: Info:eu-repo/semantics/article Palavras-chave: HTLV-I; TSP/HAM; Retrovirus; Molecular mimicry. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200013 Registros recuperados: 2 Primeira ... 1 ... Última

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