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Influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations 60
Ayorinde,John Oluwasogo; Itiola,Oludele Adelanwa; Odeku,Oluwatoyin Adepeju; Odeniyi,Michael Ayodele.
The influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations were studied using a novel gum from Albizia zygia. Tablets were produced from diclofenac formulations containing corn starch, lactose and dicalcium phosphate. Formulations were analyzed using the Heckel and Kawakita plots. Determination of microbial viability in the formulations was done on the compressed tablets of both contaminated and uncontaminated tablets prepared from formulations. Direct compression imparted a higher plasticity on the materials than the wet granulation method. Tablets produced by wet granulation presented with a higher crushing strength than those produced by the direct compression method....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tablets/production; Tablets/microbial analysis; Direct compression/tablets production; Wet granulation/tablets production; Tablets/microbial contamination; Microbial survival/in tablets; Albizia gum/use; Albizia gum/tablets production.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400022
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