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| Beg,Sarwar; Nayak,Amit Kumar; Kohli,Kanchan; Swain,Suryakanta; Hasnain,MS. |
| The aim of present study was the assessment of antimicrobial activity of prepared time-dependent release bilayer tablets of amoxicillin trihydrate and in vitro evaluation of drug release by antimicrobial assay using agar plate diffusion method. The bilayer tablets comprised of a delayed and sustained release layer. Direct compression method was used for the preparation of bilayer tablets containing Eudragit-L100 D55 as delayed release polymer, and HPMCK4M and HPMCK15 as sustained release polymers. The prepared bilayer tablets containing amoxicillin trihydrate were evaluated for hardness, thickness, friability, weight variation and drug content. Further, in vitro drug release was assessed by antimicrobial assay using S. aureus and E. coli as test... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronotherapeutics; Time-dependent release; In vitro dissolution; Minimum inhibitory concentration; Zone of inhibition. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200010 |
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| Hales,Dana; Dumitrașcu,Dan Lucian; Tomuță,Ioan; Briciu,Corina; Muntean,Dana-Maria; Tefas,Lucia Ruxandra; Iurian,Sonia; Iovanov,Rareș Iuliu; Achim,Marcela; Vlase,Laurian. |
| ABSTRACT The aim of this study was to formulate and prepare compression-coated tablets for colonic release (CR-tablets), and to evaluate the bioavailability of ketoprofen following the administration of a single dose from mini-tablets with immediate release (IR-tablets) compared to CR-tablets. CR-tablets were prepared based on time-controlled hydroxypropylmethylcellulose K100M inner compression-coating and pH-sensitive Eudragit® L 30D-55 outer film-coating. The clinical bioavailability study consisted of two periods, in which two formulations were administered to 6 volunteers, according to a randomized cross-over design. The apparent cumulative absorption amount of ketoprofen was estimated by plasma profile deconvolution. CR-tablets were able to delay... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Colonic delivery; Compression-coated tablets; PH-Dependent release; Time-dependent release; In vitro-in vivo comparison. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400609 |
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