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| Registros recuperados: 612 | |
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| Julia Hyman; Arthur Gold; Kelly Addy; Ken Forshay; Paul Mayer; Peter Groffman. |
| a)	Background/Question/Methods
Watersheds have a profound capacity to retain and remove nitrogen (N) inputs before entering coastal waters thereby minimizing eutrophication and hypoxia in estuarine waters. Research suggests that much of this N cycling occurs within aquatic ecosystems, e.g., lakes, streams and wetlands, which may become “hotspots” of nitrous oxide (N2O) production. We examined the effects of woody debris on nitrate removal and denitrification rates in streams of different N enrichment levels. Three different standardized substrates (fresh wood blocks, bundles of naturally occurring streambed wood, and clay‐fired blocks) that were expected to vary in their pool of labile carbon were... |
| Tipo: Poster |
Palavras-chave: Ecology; Earth & Environment. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5284/version/1 |
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| Angelika Ziegler; Wenke Mönkemeyer; Ralf Wilhelm; Kerstin Schmidt. |
| Directive 2001/18 EC demands the cultivation of genetically modified organisms (GMO) to be accompanied by post-market environmental monitoring (PMEM). It is composed of a general surveillance for unanticipated adverse effects and case specific monitoring (CSM), which is set up to reduce substantial uncertainties in relevant risk scenarios identified in the environmental risk assessment. PMEM should also allow early identification of potential long-term effects of cultivating GMOs. It should facilitate decisions in risk management.
In this project, a method for a Europe-wide CSM was to be developed. Starting with critical questions from ERA, exposure scenarios (first for non target organisms, later for all other partitions of the ERA) were... |
| Tipo: Poster |
Palavras-chave: Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4472/version/1 |
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| Nainaru Ganesh; Dibyabhaba Pradhan; Amineni Umamaheswari. |
| Protein kinases are clinically relevant and attractive drug targets for most of the cancerous diseases. Ribosomal protein s6 kinase (P70s6 kinase) is a mitogen activated Ser/Thr protein kinase, essential for cell growth, G1 cell cycle progression and cell survival. Human P70s6 kinase is involved in different signaling pathways and phosphorylates the downstream S6 protein of the 40S ribosomal subunit there by controlling the translational activity. Over expression of human P70s6 or rapid amplification of gene (RPS6KB1) leads to rapid cell proliferation causing cancer in various organs of humans like colon, breast, ovary, etc. The over expression is principally due to activation of some phosphorylating sites or ATP binding sites in the domain regions. In the... |
| Tipo: Poster |
Palavras-chave: Cancer; Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4906/version/1 |
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| Natarajan Pradeep; Dibyabhaba Pradhan; Amineni Umamaheswari. |
| Oncogenic constitutive enzyme human p38γ is a serine/threonine protein kinase, activated through phosphorylation by environmental stress and pro-inflammatory cytokines responses. Breast cancer, hepatoma, colon cancer, atherosclerotic lesion (coronary artery lesion / hardening of artery), hypertension and inflammations are some of the diseases caused by human p38γ due to over expression. Over expression of the protein in turn induces anti-apoptosis and inflammatory responses, increased malignant transformation and cell differentiation. Thus, designing potent inhibitors against p38γ would be highly practicable for development of novel means of breast cancer therapeutics. Extensive preclinical data and proteomic analysis support... |
| Tipo: Poster |
Palavras-chave: Cancer; Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4904/version/1 |
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| Andreas Mayr; Djork-Arne Clevert; Sepp Hochreiter. |
| One of the main topics in systems biology is to model genetic pathways. Genes of a pathway, which show linear dependencies of their expression values, are easy to identify to belong to the pathway. However, if feedback loops or signal cascades are present, gene expression values of pathway genes can be nonlinearly dependent on the expression values of other genes in the pathway. In this situation such genes are hard to detect as belonging to the pathway because nonlinearity and noise must be distinguished.

We propose an algorithm to infer nonlinear network elements in pathways from microarray data. Our model assumes, that gene expression values, belonging to one pathway, are mainly driven by one single latent factor. We... |
| Tipo: Poster |
Palavras-chave: Bioinformatics. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4715/version/1 |
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| Masaki Miyamoto. |
| Using modern TV-endoscope equipment, we have experimented image processing in several ways. This time, we designed new image processing unit called “Color Subtracted Enhancement image processing unit”. This unit　was made by combining the RGB-Subtraction　image processing device with the color enhancement image processing device. The　RGB-subtraction device is an analogue unit that　enables us to remove the visible red, green and blue peaks from the image. We can subtract the images R-G, R-B, G-R, B-R, B-G simply by changing the switches. The color enhancement device (developed by Olympus optical corporation inc.) is a digital processing unit that lets us reinforce any of these colors. This... |
| Tipo: Poster |
Palavras-chave: Cancer. |
| Ano: 2008 |
URL: http://precedings.nature.com/documents/2255/version/1 |
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| Patrick Gürtler; Esther Meissner; Ulrich Busch. |
| Import and planting of biotech crops is strictly regulated in Europe. In order to observe these strict regulations, an efficient surveillance of the European market is required. In Europe, data on authorised biotech crops from foreign countries are on hand, however, only scarce information on non-authorised biotech crops is available. Experience of the last years has shown that non-authorized biotech crops (e.g. biotech-papaya, Bt10-maize, LL601-rice and Bt63-rice) were detected on the European market. The Bavarian Health and Food Safety Authority is responsible for the detection of illegal imports and for labelling control of Food and Feed in Bavaria (Germany). The quantitative real-time PCR is the method of choice for the detection of genetic... |
| Tipo: Poster |
Palavras-chave: Biotechnology; Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4444/version/1 |
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| Carsten C. Mahrenholz; Victor Tapia; Rolf Stigler; Rudolf Volkmer. |
| There are several methods commonly used to measure protein-protein interactions and binding affinities. Quite contrary to most of these methods, protein- and peptide arrays on cellulose membranes or glass slides are suitable for high-throughput measurement, as they provide a higher density of probes and a multitude of peptide-protein interactions can be measured in parallel [1]. The most important application of the SPOT synthesis technique is to simultaneously detect a high number of peptides that have a strong binding affinity to defined targets. The validity of the results, however, depends on the ability of the detection system to indicate binding events whilst not interfering with the experiment itself through cross reaction. We tested three common... |
| Tipo: Poster |
Palavras-chave: Biotechnology; Chemistry. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4448/version/1 |
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| Tim Beck; John M. Hancock; Ann-Marie Mallon. |
| The use of the Entity + Quality (EQ) model in phenotypic descriptions is dependent on the use of specialised domain ontologies to define the entity under observation. A domain currently lacking a specialised ontology is mammalian behaviour, and so the Mammalian Behaviour Ontology is being constructed to address this. Top-level class distinctions are made between behavioural activities and behavioural functions of individuals, and those between two or more individuals. The ontology is manually developed and encourages contributions from domain experts. |
| Tipo: Poster |
Palavras-chave: Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3565/version/1 |
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| James Malone; Tomasz Adamusiak; Ele Holloway; Helen Parkinson. |
| The Experimental Factor Ontology ("www.ebi.ac.uk/efo":http://www.ebi.ac.uk/efo) is an application focused ontology modelling the experimental factors in ArrayExpress. The ontology has been developed to increase the richness of the annotations that are currently made in the ArrayExpress repository, to promote consistent annotation, to facilitate automatic annotation and to integrate external data. The methodology employed in the development of EFO involves construction of mappings to multiple existing domain specific ontologies, such as the Disease Ontology and Cell Type Ontology. |
| Tipo: Poster |
Palavras-chave: Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3806/version/1 |
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| Nadine Drechsler; Antje Habekuß; Thomas Thieme; Jörg Schubert. |
| Enhanced or reduced uptake of viruses by vectors and changes in resistance level can be sensitive indicators for metabolic changes in transgenic plants caused by the new trait and not observed by conventional methods. In addition, the plant transformation process itself can lead to such changes. To be able to investigate this hypothesis in cereals we decided to use two highly important insect-transmitted viruses infecting them - _Barley yellow dwarf virus_ (BYDV) and _Wheat dwarf virus_ (WDV). Corresponding molecular tools for their quantification in plants as well as virus vectors had to be developed. 
Both viruses cause similar symptoms: dwarfing, stunting, leaf discoloration leading to yield losses or death of plant. BYDV... |
| Tipo: Poster |
Palavras-chave: Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4493/version/1 |
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| Anja Hühnlein; Jörg Schubert; Thomas Thieme. |
| Genetically modified plants (GMPs) have to pass several safety evaluations before they can be approved but identification of undesired changes in metabolism is hard to achieve due to its complexity. Such unexpected changes could be reflected by changes in virus resistance and feeding behaviour of herbivores such as aphids. Altered behaviour can be determined by so- called life table statistics where e. g. the lifetime and the reproduction rate are analysed. Such experiments are time consuming and costly. The behaviour alterations should also be detectable by changes in virus uptake und transmission. Thus, quantitative detection methods are needed in order to measure the absolute virus content in plants and in aphids. _Potato leafroll virus_ (PLRV) and... |
| Tipo: Poster |
Palavras-chave: Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4473/version/1 |
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| Christine Höflich; Andreas Müller; Jörg Schmidtke; Kerstin Schmidt; Inge Broer. |
| Transgenic plants need specific approaches to analyse their potential impact on environment and consumer. The procedures used to date are often too extensive and time-consuming and associated with high costs. The BioOK network was established to develop an effective and competitive risk assessment on transgenic plants based on interdisciplinary research. New and effective methods for the risk assessment were established which focus on transgene-specific effects measured in in vitro systems in the laboratory or greenhouse whenever possible. Nevertheless event-specific field experiments have to be carried out in addition to implement environmental effects e.g. on non-targets or the variability of transgene expression.

The... |
| Tipo: Poster |
Palavras-chave: Biotechnology; Bioinformatics; Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4438/version/1 |
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| Christine Höflich; Andreas Müller; Jörg Schmidtke; Kerstin Schmidt; Inge Broer. |
| Transgenic plants need specific approaches to analyse their potential impact on environment and consumer. The procedures used to date are often too extensive and time-consuming and associated with high costs. The BioOK network was established to develop an effective and competitive risk assessment on transgenic plants based on interdisciplinary research. New and effective methods for the risk assessment were established which focus on transgene-specific effects measured in in vitro systems in the laboratory or greenhouse whenever possible. Nevertheless event-specific field experiments have to be carried out in addition to implement environmental effects e.g. on non-targets or the variability of transgene expression.

The... |
| Tipo: Poster |
Palavras-chave: Biotechnology; Bioinformatics; Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4438/version/2 |
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| Carla Struzyna-Schulze; Heike Mikschofsky; Wenke Mönkemeyer; Jörg Schmidtke; Kerstin Schmidt; Inge Broer. |
| Transgenic plants often produce proteins that are unknown in conventional crops. Therefore, it requires a fundamental analysis before approval of a new genetically modified plant is given. Since the EFSA-guidelines for risk assessment on transgenic plants provide only recommendations but no detailed instructions, we wanted to develop a valid test scheme that defines sample size and sampling organ to enable a statically valid and efficient analysis of transgene expression and its variability. The scheme will be based on data obtained for the variability in expression i. of different recombinant proteins in one variety; ii. of different integration sites of one transgene in one variety; iii. of the same recombinant protein between different varieties and... |
| Tipo: Poster |
Palavras-chave: Biotechnology; Plant Biology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/4443/version/1 |
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| Michelle Giglio; Chris Mungall; Peter Uetz; Lanlan Yin; Johannes Goll; Deborah Siegele; Marcus Chibucos; James Hu. |
| *Abstract*
Phenotypic data are routinely used to elucidate gene and protein function in most organisms amenable to experimental manipulation. However, although phenotype ontologies exist for many eukaryotic model organisms, no standardized system exists for the capture of phenotypic information in bacteria. We propose to build an Ontology of Microbial Phenotypes and use it to annotate the prokaryotic model organism _Escherichia coli_.

*Introduction*
Phenotypes are the observable characteristics of an organism that result from the combination of a particular genotype and a particular environment, and thus are a basic and fundamental aspect of the biology of all organisms. The awesome power... |
| Tipo: Poster |
Palavras-chave: Microbiology; Bioinformatics. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3639/version/1 |
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| Jennifer Redman; Michael T. Calkins; Mark C. Andersen; Kenneth G. Boykin. |
| The Swift fox (Vupes velox) is a habitat specialist species of short or mixed grass prairie. We used bioclimatic envelope models and habitat suitability models under three future climate scenarios (based on CO2 emission rates) from "www.climatewizard.org":http://www.climatewizard.org to fit species distribution models, using the maximum entropy method. Current suitable habitat for the swift fox covers an area of 161,984 km2. Under the future climate scenarios the habitat decreases by 27% in the low emission scenario, 63% for medium emissions, and 53% in the high emissions scenario. This decrease in suitable habitat corresponded to an overall decrease in total grassland landcover. The current total area of grassland is 423,440 km2. Under... |
| Tipo: Poster |
Palavras-chave: Ecology; Earth & Environment. |
| Ano: 2009 |
URL: http://precedings.nature.com/documents/3717/version/1 |
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| Registros recuperados: 612 | |
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