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Registros recuperados: 62
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Bovine Rena Cell Carcinoma with Marked Connective-tissue Proliferation OAK
立石, 識子; 古林, 与志安; 黒沢, 重人; 大林, 哲; 古岡, 秀文; 松井, 高峯; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi.
直腸検査により, 左腎相当部に巨大腫瘤が触知された4歳齢, 雌のホルスタイン牛を病理学的に検索した. 肉眼的に左腎は硬く, 褪色し, 分葉構造を保ちつつ顕著に腫大していた. 左腎割面では腎実質の大部分は白色硬組織により置換されていた. また, 左腎門リンパ節から左内腸骨リンパ節にかけて直径1-10cmの白色硬組織からなる腫瘤が密在していた. 組織所見では左腎に著しい結合組織増生を伴う上皮性腫瘍細胞の不整管状増殖がび漫性に認められ, 実質を置換していた. 同様の腫瘍組織は他の白色硬組織でも観察された. これらの腫瘍細胞は抗ウロモジュリン抗体に陽性を示した. 超微形態学的に腫瘍細胞には微絨毛とデスモゾームが認められた. 以上の所見から本症例を顕著な結合組織の増生を伴う腎細胞癌と診断した.
Palavras-chave: ; 腎細胞癌; ウロモジュリン.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4171
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BSEの病理診断法の改良および感染マウスに関する病理学的研究 OAK
古岡, 秀文.
発行年は推定
Ano: 2007 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3525
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BSE(牛海綿状脳症)の診断法 OAK
古岡, 秀文.
Palavras-chave: BSE; 病理; 診断.
Ano: 2006 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/894
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Comparison of Bacterial Endotoxin Lipopolysaccharide Concentrations in the Blood, Ovarian Follicular Fluid and Uterine Fluid: A Clinical Case of Bovine Metritis OAK
MAGATA, Fumie; ISHIDA, Yoshikazu; MIYAMOTO, Akio; FURUOKA, Hidefumi; INOKUMA, Hisashi; SHIMIZU, Takashi; 宮本, 明夫; 古岡, 秀文; 猪熊, 壽; 清水, 隆.
We investigated the concentration of the bacterial endotoxin lipopolysaccharide (LPS) in the blood, ovarian follicular fluid and uterine fluid of a clinical case of bovine metritis. A 2-year-old lactating Holstein cow exhibited continuous fever >39.5°C for more than 2 weeks after normal calving. The cow produced a fetid, watery, red-brown uterine discharge from the vagina and was diagnosed with metritis. The LPS concentrations in plasma and uterine fluid were 0.94 and 6.34 endotoxin units (EU)/ml, respectively. One of seven follicles showed an extremely high level of LPS (12.40 EU/ml) compared to the other follicles (0.62–0.97 EU/ml). These results might suggest the presence of high concentration of LPS in follicles in cows with postpartum metritis.
Palavras-chave: Dairy cow; Follicle; Lipopolysaccharide; Metritis.
Ano: 2015 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4043
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Comparison of Enterotoxicity between Autumn Crocus (Colchicum autumnale L.) and Colchicine in the Guinea Pig and Mouse : Enterotoxicity in the Guinea Pig Differs from That in the Mouse OAK
YAMADA, Manabu; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; MATSUI, Takane; 古林, 与志安; 古岡, 秀文.
Autumn crocus poisoning of cattle is characterized by severe diarrhea caused by alkaloid colchicine. Previously, we examined pathologically this poisoning in cattle and reported that enterotoxic lesions were closely associated with apoptosis. To examine enterotoxicity of autumn crocus more precisely, a reproductive study was performed using guinea pigs and mice, and pathological findings associated with autumn crocus poisoning were compared with those of colchicine. Each group of guinea pigs given the bulb of autumn crocus or colchicine exhibited severe diarrhea. Histopathological findings in intoxicated guinea pigs were entirely consistent with those in the autumn crocus-poisoned cattle. In contrast, each group of mice administered with the bulb or...
Palavras-chave: Apoptosis; Autumn crocus (Colchicum autumnale L.); Colchicine; Guinea pig; Mouse.
Ano: 2000 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4170
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Detection of the nonsense mutation of OPA3 gene in Holstein Friesian cattle with dilated cardiomyopathy in Japan OAK
HORIUCHI, Noriyuki; KUMAGAI, Daishiro; MATSUMOTO, Kotaro; INOKUMA, Hisashi; FURUOKA, Hidefumi; KOBAYASHI, Yoshiyasu; 松本, 高太郎; 猪熊, 壽; 古岡, 秀文; 古林, 与志安.
Bovine dilated cardiomyopathy (DCM) is an autosomal recessive genetic disorder causing congestive heart failure and subsequent death. Recently, a nonsense mutation c.343C>T in the bovine optic atrophy 3 (OPA3) gene had been reported to cause the DCM in Holstein cattle in Switzerland. However, the mutation has not been confirmed in bovine DCM outside Switzerland. Nine Holstein Friesian cows that were macroscopically and histologically diagnosed with or suspected of DCM and 12 control cows kept in Japan were tested for the mutation. The mutation surrounding OPA3 DNA fragment was amplified by PCR and subjected to direct sequences. The homogeneous c.343C>T mutation was proved to occur in all the affected cows and not in the control cows. The present...
Palavras-chave: Cattle; Dilated cardiomyopathy; Nonsense mutation; OPA3 gene.
Ano: 2015 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4208
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Evaluation of Gene Expression in Peripheral Blood Cells as a Potential Biomarker for Enzootic Bovine Leukosis OAK
TAWFEEQ, Mohammad Monir; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; INOKUMA, Hisashi; 堀内, 雅之; 古林, 与志安; 古岡, 秀文; 猪熊, 壽.
Expression of six selective genes in peripheral blood cells was evaluated as diagnostic biomarkers for enzootic bovine leukosis (EBL) by using 10 EBL and 15 clinically healthy cattle. The clinically healthy cattle generally showed lower gene expression levels. Although wide variations of gene expression were found in some clinical cases of EBL, 4 and 5 among 10 EBL cattle showed higher expression of interleukin 2 receptor gene (IL2R) and Wilms’ tumor gene (WT1), respectively. Expression of IL2R in peripheral blood cells in EBL cattle was statistically increased; however, the lower sensitivity and higher variation in the gene expressions among clinical cases of EBL would be problems as diagnostic biomarkers.
Palavras-chave: Biomarkers; Enzootic bovine leukosis; Gene expression; QRT-PCR.
Ano: 2013 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3868
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First Case of Echinococcus multilocularis Infection in a Zoo-Housed Flying Squirrel (Pteromys volans orii) OAK
OIKAWA, Eri; SHIMURA, Ryoji; NISHIMURA, Maki; FURUOKA, Hidefumi; 古岡, 秀文.
A 33 month-old male flying squirrel kept in a zoo developed progressive dyspnea and died. Macroscopically, the liver and lung were enlarged with numerous nodular vesicles. Histologically, these organs were replaced by numerous collapsed vesicles demarcated by fibrous tissues. The cysts lined by a cellular, germinal layer contained numerous brood capsules with abundant production of well-developed protoscolices. Protoscolices were about 80–100 μm in diameter, and had hooks being visible as refractive structures. This zoo locates in the east of Hokkaido where is an endemic area of Echinococcus multilocularis infection. From epidemiology and pathological findings, this animal was diagnosed as E.multilocularis infection. This report describes the pathology of...
Palavras-chave: Echinococcus multilocularis; Flying squirrel; Hokkaido; New host record; Pathology.
Ano: 2013 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3944
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HSP70欠損牛の臨床学的・病理学的研究 OAK
古岡, 秀文; 佐藤, 基佳; 大星, 健治; 山岸, 則夫; Furuoka, Hidefumi; Sato, Motoyoshi; Ohoshi, Kenji; Yamagishi, Norio.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2139
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HSP70欠損牛の臨床学的・病理学的研究 OAK
古岡, 秀文; 佐藤, 基佳; 大星, 健治; 山岸, 則夫; Furuoka, Hidefumi; Sato, Motoyoshi; Ohoshi, Kenji; Yamagishi, Norio.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2138
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Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3 beta in N1E-115 neuroblastoma cells OAK
Ishii, Toshiaki; Furuoka, Hidefumi; Muroi, Yoshikage; Nishimura, Masakazu; 石井, 利明; 古岡, 秀文; 室井, 喜景.
Integrin-linked kinase (ILK) is a focal adhesion serine/ threonine protein kinase with an important role in integrin and growth factor signaling pathways. Recently, we demonstrated that ILK is expressed in N1E-115 neuroblastoma cells and controls integrin-dependent neurite outgrowth in serum-starved cells grown on laminin (Ishii, T., Satoh, E., and Nishimura, M. ( 2001) J. Biol. Chem. 276, 42994 - 43003). Here we report that ILK controls tau phosphorylation via regulation of glycogen synthase kinase-3beta (GSK-3beta) activity in N1E-115 cells. Stable transfection of a kinase-deficient ILK mutant (DN-ILK) resulted in aberrant tau phosphorylation in N1E-115 cells at sites recognized by the Tau-1 antibody that are identical to some of the phosphorylation...
Palavras-chave: ALZHEIMERS-DISEASE NEURITE OUTGROWTH PROTEIN; NEURONS HYPERPHOSPHORYLATION KINASE-3-BETA ACCUMULATION BINDING ROLES.
Ano: 2003 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/747
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MDCT Images of the Head of a Horse with Malignant Melanoma OAK
SASAKI, Naoki; MINAMI, Takuto; YAMADA, Kazutaka; SATOH, Motoyoshi; INOKUMA, Hisashi; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; YAMADA, Haruo; 佐々木, 直樹; 山田, 一孝; 猪熊, 壽; 古林, 与志安; 古岡, 秀文.
A 17-year-old, gray Thoroughbred gelding was presented with recurrent epistaxis following exercise for over one year. Multidetector-row computed tomographic (MDCT) examination of the head performed under general anesthesia indicated the presence of malignant melanoma. MDCT examination revealed the exact location and size of masses in the right guttural pouch first identified by endoscopy and in the left guttural pouch unidentified by endoscopy. MDCT examination revealed the presence of a blood clot that filled the right maxillary sinus. The horse was euthanized due to poor prognosis as a riding horse and the owner's decision, and MDCT findings were confirmed by postmortem examination. MDCT is suggested as a useful technique for diagnosis of head problems...
Palavras-chave: Equine; Malignant melanoma; MDCT.
Ano: 2007 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3104
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Optic pathway degeneration in Japanese black cattle OAK
CHIBA, Shiori; FUNATO, Shingo; HORIUCHI, Noriyuki; MATSUMOTO, Kotaro; INOKUMA, Hisashi; FURUOKA, Hidefumi; KOBAYASHI, Yoshiyasu; 堀内, 雅之; 松本, 高太郎; 猪熊, 壽; 古岡, 秀文; 古林, 与志安.
Degeneration of the optic pathway has been reported in various animal species including cattle. We experienced a case of bilateral optic tract degeneration characterized by severe gliosis in a Japanese black cattle without any obvious visual defects. To evaluate the significance, pathological nature and pathogenesis of the lesions, we examined the optic pathway in 60 cattle (41 Japanese black, 13 Holstein and 6 crossbreed) with or without ocular abnormalities. None of these animals had optic canal stenosis. Degenerative changes with severe gliosis in the optic pathway, which includes the optic nerve, optic chiasm and optic tract, were only observed in 8 Japanese black cattle with or without ocular abnormalities. Furthermore, strong immunoreactivity of...
Palavras-chave: Axonal degeneration; Gliosis; Japanese black cattle; Optic pathway degeneration.
Ano: 2015 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4123
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Pathology of naturally occurring porcine adenovirus type 4 infection in Japan OAK
Agungpriyono, Dewi Ratih; Nakagawa, Michio; Morozumi, Tetsuo; Yoshihara, Shinobu; Furuoka, Hidefumi; Matsui, Takane; アグリプリヨノ, デヴィ ラテイ; 中川, 迪夫; 両角, 徹雄; 吉原, 忍; 古岡, 秀文; 松井, 高峯.
Palavras-chave: Adenovirus; Encephalitis; Inclusion body; Nephritis; Swine.
Ano: 1997 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/1326
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Proliferative Enteropathy Involving Lawsonia intracellularis Infection in Rabbits (Oryctlagus cuniculus) OAK
HORIUCHI, Noriyuki; WATARAI, Masahisa; KOBAYASHI, Yoshiyasu; OMATA, Yoshitaka; FURUOKA, Hidefumi; 堀内, 雅之; 古林, 与志安; 古岡, 秀文.
Five rabbits suffering from diarrhea were diagnosed with proliferative enteropathy (PE). Histopathology revealed a thickened mucosa consisting of hyperplastic intestinal epithelium and infiltration of inflammatory cells mainly consisted of macrophages. In the affected epithelial cytoplasm, numerous curved bacillus-like organisms were observed in the Warthin-Starry silver stain and electron microscopy observation. In polymerase chain reactions, Lawsonia intracellularis-specific DNA fragment were amplified from affected ileal tissue extracted DNA in each case and present 5 cases were confirmed to be L. intracellularis infection. Serum collected from the affected rabbit was immunohistochemically reactive with L. intracellularis in tissue sections from pigs...
Palavras-chave: Lawsonia intracellularis; Proliferative enteropathy; Rabbit.
Ano: 2008 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4169
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The mesencephalic trigeminal sensory nucleus is involved in acquisition of active exploratory behavior induced by changing from a diet of exclusively milk formula to food pellets in mice OAK
Ishii, Toshiaki; Furuoka, Hidefumi; Kitamura, Nobuo; Muroi, Yoshikage; Nishimura, Masakazu; 古岡, 秀文; 北村, 延夫; 室井, 喜景; 石井, 利明.
Post-weaning mice fed exclusively milk display low-frequency exploratory behavior [Ishii, T., Itou, T., and Nishimura, M. (2005) Life Sci. 78, 174-179] compared to mice fed a food pellet diet. This low-frequency exploratory behavior switched to high-frequency exploration after a switch from exclusively milk formula to a food pellet diet. Acquisition of the high-frequency exploratory behavior was irreversible. Recently, we demonstrated that the mesencephalic trigeminal nucleus (Me5) is involved in the control of feeding and exploratory behavior in mice without modulating the emotional state [Ishii, T., Furuoka, H., Itou, T., Kitamura, N., and Nishimura, M. (2005) Brain Res. 1048, 80-86]. We therefore investigated whether the Me5 is involved in acquisition...
Palavras-chave: Exploratory behavior; Me5 lesions; Weaning.
Ano: 2006 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/739
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Three Cases of Atypical Bovine Leukosis in Holstein Cows OAK
田川, 道人; 下田, 崇; 富樫, 義彦; 渡辺, 由紀; 古林, 与志安; 古岡, 秀文; 石井, 三都夫; 猪熊, 壽; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; ISHII, Mitsuo; INOKUMA, Hisashi.
体表リンパ節の腫脹, 末梢血中における異型リンパ球出現を伴うリンパ球数の著増などの典型的な牛白血病症状を示していなかったことから, それぞれアミロイドーシス, 胸膜炎, 心疾患が疑われた3頭のホルスタイン種乳雌牛を病理解剖したところ, いずれも牛白血病と診断された. 血液検査および身体検査において著変が観察されない場合でも, 難診断時には鑑別診断リストに牛白血病を加えるべきであると考えられた.
Palavras-chave: 非典型的牛白血病; 鑑別診断.
Ano: 2008 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4005
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Ultrasound Imaging of Mammary Glands in Dairy Heifers at Different Stages of Growth OAK
NISHIMURA, Maki; YOSHIDA, Tetsuya; EL-KHODERY, Sabry; MIYOSHI, Masafumi; FURUOKA, Hidefumi; YASUDA, Jun; MIYAHARA, Kazuro; 古岡, 秀文; 宮原, 和郎.
To obtain B-mode ultrasound images of mammary glands in dairy heifers at different stages of growth, 25 clinically normal Holstein heifers were used. The heifers were divided into 5 groups (n=5/group) by stage of their growth: 2-month-old (group 1), 5-month-old (group 2), postpuberty (group 3), mid (group 4), and late (group 5) pregnancy. Furthermore, the sections of mammary glands were observed grossly at postmortem examination in one heifer in each group. Ultrasound images varied with the development of mammary glands. In group 1, the mammary glands had distinctive ultrasonographic findings: an oval to fusiform homogeneous hypoechoic structure. In all groups except group 1, mammary tissue consists of two major areas: a homogeneous, medium echogenic area...
Palavras-chave: Dairy heifer; Mammary gland; Ultrasound.
Ano: 2011 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4068
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Utility of Serum Thymidine Kinase Activity Measurements for Cases of Bovine Leukosis with Difficult Clinical Diagnoses OAK
TAWFEEQ, Mohammad Monir; MIURA, Saori; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; INOKUMA, Hisashi; 堀内, 雅之; 古林, 与志安; 古岡, 秀文; 猪熊, 壽.
This study evaluated the clinical usefulness of serum thymidine kinase (TK) activity for diagnosing bovine leukosis cases for which clinical diagnosis was difficult (‘BL with difficult diagnosis’). Median TK activity values in 24 ‘BL with difficult diagnosis’ and 36 cattle for which BL was clinically confirmed by cytology findings of enlarged superficial lymph nodes (‘clinically confirmed BL’) were 36.8 and 39.4 U/l, respectively (no significant difference). The percentage with positive TK activity (>5.4 U/l) was also similar in both groups (83.3% for ‘BL with difficult diagnosis’ and 97.2% for ‘clinically confirmed BL’). TK activity was significantly higher in cows with ‘BL with difficult diagnosis’ compared to those with other tumors (N=13) and those...
Palavras-chave: Atypical bovine leukosis; Diagnosis; Thymidine kinase.
Ano: 2013 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3869
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Zygomycotic Mediastinal Lymphadenitis in Beef Cattle with Ruminal Tympany OAK
NISHIMURA, Maki; TOYOTA, Yumi; ISHIDA, Yoshikazu; NAKAYA, Hideki; KAMEYAMA, Kyohko; NISHIKAWA, Yoshifumi; MIYAHARA, Kazuro; INOKUMA, Hisashi; FURUOKA, Hidefumi; 西川, 義文; 猪熊, 壽; 古岡, 秀文.
A 9-month-old steer was autopsied due to recurrent ruminal tympany. A macroscopic examination found an enlarged caudal mediastinal lymph node, and a section of the lymph node revealed necrosis with marked calcification, similar to tuberculous lymphadenitis. Histopathologically, the lesion consisted of multiple coagulative necrotic foci and fibrosis with macrophage, lymphocyte, eosinophil and multinucleated giant cell infiltration. Non-uniform width hyphae were detected in the necrotic area and within the cytoplasm of the multinucleated giant cells, and they were found to be anti-Rhizopus arrhizus antibody positive in an immunohistochemical examination. Therefore, the steer was diagnosed with necrotic caudal mediastinal lymphadenitis due to zygomycetes...
Palavras-chave: Cattle; Necrotic lymphadenitis; Ruminal tympany; Zygomycosis.
Ano: 2014 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3943
Registros recuperados: 62
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