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| LEMES,SUSY R.; CHAVES,DWIGHT A.; SILVA JÚNIOR,NELSON J. DA; CARNEIRO,CRISTIENE C.; CHEN-CHEN,LEE; ALMEIDA,LUCIANE M. DE; GONÇALVES,PABLO J.; MELO-REIS,PAULO R. DE. |
| ABSTRACT The aim of this study was to evaluate the possible protective of C. guianensis oil against MMC and CP, which are direct- and indirect-acting chemical mutagens, using the micronucleus test. Three experiments were performed. First the C. guianensis oil was co-administered to mice at doses of 250, 500 and 1000 mg/kg bw with 4 mg/kg bw MMC or 50 mg/kg bw CP. Second, the mutagenic drug (CP) was administered ip 50 mg/kg bw and after 6 and 12 hours 250 and 500 mg/kg bw of C. guianensis oil were administered. In the last, C. guianensis oil was administrated (250 and 500 mg/kg bw) during five days and after it was administered ip 50 mg/kg bw CP. The results obtained showed that the C. guianensis oil is not cytotoxic neither genotoxic to mouse bone marrow.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antigenotoxic; Carapa guianensis; Micronucleus; Oil. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000502043 |
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| SOUSA,WENDEL C. DE; T.S. PAZ,ANDRESSA; ROCHA,JAMIRA D.; CONCEIÇÃO,EDEMILSON C. DA; ALMEIDA,LUCIANE M. DE; CHEN,LEE C.; BORGES,LEONARDO L.; BAILÃO,ELISA F.L.C.. |
| ABSTRACT Costus spiralis is a Brazilian native plant used in popular medicine, but the safety of this therapeutic use needs investigation. So, the aim of this study was to evaluate the cytogenotoxic and antigenotoxic effects of C. spiralis leaves or stems aqueous extracts on Allium cepa root cells. Moreover, a phytochemical screening and an antioxidant and antifungal activities evaluation were performed. C. spiralis aqueous extracts presented cytotoxicity, but no mutagenicity was observed. When the antigenotoxicity was evaluated, C. spiralis leaves aqueous extract presented preventive and modulatory effects on A. cepa root cells, reducing the sodium azide cytogenotoxic effects. In contrast, C. spiralis stems aqueous extract enhanced the sodium azide... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Allium cepa test; Antioxidant; Medicinal plant; Secondary metabolites. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000401565 |
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