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A Blower-like approach to predict the effectiveness of vaccines in a TB dynamic. Repositório Alice
FRONZA, C. F.; ANSELMO, J.; MARQUES, J. L. B.; PINTARELLI, G. B.; CASTRO, A. de..
In this paper we present an extension of an automata approach proposed by S. Blower (1998) to describe the tuberculosis progression in a bi-dimensional space. In our extended model, the vaccination was included as an inhibitory variable in order to study its influence on the behavior of the tuberculosis spread. Our simulations showed that the earlier the vaccine is administered in the population, the lower the number of infected individuals, as expected for an in vivo system. However, our results also indicated that although the usual vaccination processes help reducing the strength of infection, the disease is not extinct, remaining the endemic state at low levels. These results strongly suggest that further actions are needed to increase the...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Simulação; Cellular automata; Tuberculose; Tuberculosis; Computer simulation.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/990390
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Computational approach of the homeostatic turnover of memory B cells. Repositório Alice
CASTRO, A. de; FRONZA, C. F.; ANSELMO, J..
In this paper, a discrete mathematical model inspired by control mechanisms is used to explore the factors potentially responsible for maximum immunization capacity in mammals. The results have been discussed in light of recent work, and refer to the adoption of parameter values chosen among data gathered from the literature. The model used in this study took into consideration that the immune system is a network of molecules and cells that can recognize itself.
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Células B; Memória imune; Immune memory; Homeostatic turnover; Equilíbrio homeostático; Modelo matemático; Mathematical models; Memory.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/999572
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