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	Provedor de dados BJMBR (3) Autor Alvarez-Silva,M. (3) Trentin,A.G. (2) Vituri,C.L. (2) Borelli,P. (1) Jeremias,T.S. (1) Licínio,M.A. (1) Santos-Silva,M.C. (1) Soares,P.B. (1) Mais... Palavra-chave Bone marrow (1) Bone marrow stromal cell (1) Differentiation (1) Extracellular matrix (1) Fibronectin (1) GFAP (1) Glioma (1) Hematopoietic progenitors (1) Imatinib mesylate (1) Malnutrition (1) Myelosuppression (1) Protein synthesis (1) Thyroid hormone (1) Vimentin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Info:eu-repo/semantics/other (1) Ano 2013 (1) 2000 (1) 1998 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Alterations in proteins of bone marrow extracellular matrix in undernourished mice BJMBR Vituri,C.L.; Alvarez-Silva,M.; Trentin,A.G.; Borelli,P.. The objective of the present study was to determine the effect of protein malnutrition on the glycoprotein content of bone marrow extracellular matrix (ECM). Two-month-old male Swiss mice were submitted to protein malnutrition with a low-protein diet containing 4% casein as compared to 20% casein in the control diet. When the experimental group had attained a 20% loss of their original body weight, we extracted the ECM proteins from bone marrow with PBS buffer, and analyzed ECM samples by SDS-PAGE (7.5%) and ECL Western blotting. Quantitative differences were observed between control and experimental groups. Bone marrow ECM from undernourished mice had greater amounts of extractable fibronectin (1.6-fold increase) and laminin (4.8-fold increase) when... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fibronectin; Bone marrow; Extracellular matrix; Malnutrition. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000800004 In vitro inhibitory effects of imatinib mesylate on stromal cells and hematopoietic progenitors from bone marrow BJMBR Soares,P.B.; Jeremias,T.S.; Alvarez-Silva,M.; Licínio,M.A.; Santos-Silva,M.C.; Vituri,C.L.. Imatinib mesylate (IM) is used to treat chronic myeloid leukemia (CML) because it selectively inhibits tyrosine kinase, which is a hallmark of CML oncogenesis. Recent studies have shown that IM inhibits the growth of several non-malignant hematopoietic and fibroblast cells from bone marrow (BM). The aim of the present study was to evaluate the effects of IM on stromal and hematopoietic progenitor cells, specifically in the colony-forming units of granulocyte/macrophage (CFU-GM), using BM cultures from 108 1.5- to 2-month-old healthy Swiss mice. The results showed that low concentrations of IM (1.25 µM) reduced the growth of CFU-GM in clonogenic assays. In culture assays with stromal cells, fibroblast proliferation and α-SMA expression by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Bone marrow stromal cell; Hematopoietic progenitors; Imatinib mesylate; Myelosuppression. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000100039 Thyroid hormone regulates protein expression in C6 glioma cells BJMBR Trentin,A.G.; Alvarez-Silva,M.. Thyroid hormone (T3) is essential to normal brain development. Previously, we have shown that T3 induces cerebellar astrocyte proliferation. This effect is accompanied by alteration in glial fibrillary acidic protein (GFAP) and fibronectin organization. In the present study, we report that the C6 glioma cell line, which expresses GFAP and is classified as an undifferentiated astrocytic cell type, is a target for T3 action. The C6 monolayers were treated with 50 nM T3 for 3 days, after which the cells were maintained for 2 days without medium changes. In C6 cells, T3 induced the expression of proteins of 107, 73 and 62 kDa. The hormone also up-regulated protein bands of 100 (+50%), 37 (+50%) and 25.5 kDa (+50%) and down-regulated proteins of 94 (-100%),... Tipo: Info:eu-repo/semantics/other Palavras-chave: Thyroid hormone; Glioma; Protein synthesis; GFAP; Vimentin; Differentiation. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000008 Registros recuperados: 3 Primeira ... 1 ... Última

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