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Induction of an antigen specific gut inflammatory reaction in mice and rats: a model for human Inflammatory Bowel Disease BABT
Teixeira,Gerlinde Agate Platais Brasil; Antunes,Danielle Mota Fontes; Castro Júnior,Archimedes Barbosa de; Costa,Janilda Pacheco da; Paschoal,Patrícia Olaya; Campos,Sylvia Maria Nicolau; Pedruzzi,Monique de Morais Bitetti; Araújo,Vinicius da Silva; Andrade,Luis Antônio Botelho; Moreno,Silvana Ramos Farias; Nobrega,Alberto Felix Antonio da; Cardoso,Gilberto Perez.
Food allergy is an adverse reaction that occurs in susceptible people when they eat sensitizing foods and is one of the causes of Inflammatory Bowel Disease (IBD). The effort to understand the induction process of these diseases is important as IBD is increasing worldwide, including in Brazil. The aim of this study was to develop an experimental antigen specific inflammatory process of the gut of mice and rats, using peanut seeds. Animals were immunized with peanut protein extract before their exposure to the in natura peanut seeds. Results showed that systemic immunization with peanut protein extracts rendered significantly higher antibody titers than control groups and that immunized animals submitted to a challenge diet containing peanuts presented time...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Food allergy; Peanuts; Inflammatory bowel disease; Rats; Mice.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000300012
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