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Evaluation of Cedrela gum as a binder and bioadhesive component in ibuprofen tablet formulations 60
Odeniyi,Michael Ayodele; Babalola,Adepeju Oluwadamilare; Ayorinde,John Oluwasogo.
The compressional, mechanical and bioadhesive properties of tablet formulations incorporating a new gum obtained from the incised trunk of the Cedrela odorata tree were evaluated and compared with those containing hydroxypropylmethylcellulose (HPMC). Compressional properties were evaluated using Hausner's ratio, Carr's Index, the angle of repose, and Heckel, Kawakita and Gurnham plots. Ibuprofen tablets were prepared using the wet granulation method. Bioadhesive studies were carried out using the rotating cylinder method in either phosphate buffer pH 6.8 or 0.1 M hydrochloric acid media. The gum is a low viscosity polymer (48 cPs), and Fourier transform infrared spectroscopy revealed the presence of a hydroxyl group. Py and Pk values, which are measures of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cedrela gum/evaluation; Cedrela gum/compression properties; Cedrela gum/bioadhesive component; Tablet formulations; Hydroxypropylmethylcellulose; Ibuprofen tablets/bioadhesive studies; Bioadhesion.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100011
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Influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations 60
Ayorinde,John Oluwasogo; Itiola,Oludele Adelanwa; Odeku,Oluwatoyin Adepeju; Odeniyi,Michael Ayodele.
The influence of binder type and process parameters on the compression properties and microbial survival in diclofenac tablet formulations were studied using a novel gum from Albizia zygia. Tablets were produced from diclofenac formulations containing corn starch, lactose and dicalcium phosphate. Formulations were analyzed using the Heckel and Kawakita plots. Determination of microbial viability in the formulations was done on the compressed tablets of both contaminated and uncontaminated tablets prepared from formulations. Direct compression imparted a higher plasticity on the materials than the wet granulation method. Tablets produced by wet granulation presented with a higher crushing strength than those produced by the direct compression method....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tablets/production; Tablets/microbial analysis; Direct compression/tablets production; Wet granulation/tablets production; Tablets/microbial contamination; Microbial survival/in tablets; Albizia gum/use; Albizia gum/tablets production.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400022
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