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The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB Anais da ABC (AABC)
DELOU,JOÃO M.A.; BIASOLI,DEBORAH; BORGES,HELENA L..
ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from homeostasis to support cancer cells survival, proliferation, escape from apoptosis, and therapy resistance. The relationship between autophagy and apoptosis is complex and many stimuli can induce both processes. Most chemotherapeutic agents induce autophagy and it is not clear whether and how this chemotherapy-induced autophagy might contribute to resistance to apoptosis. Here, we review current...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Retinoblastoma; Neoplasm; Autophagy; Cell death; Antineoplastic agents.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257
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