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Novel regulatory SNPs in the promoter region of the TNFRSF18 gene in a Gabonese population BJMBR
Velavan,T.P.; Bechlars,S.; Huang,X.; Kremsner,P.G.; Kun,J.F.J..
Parasites are accountable for driving diversity within immune gene families. We identified and investigated regulatory single nucleotide polymorphisms (SNPs) in the promoter regions of the tumor necrosis factor receptor superfamily member 18 (TNFRSF18) gene by direct sequencing in a group of male Gabonese individuals exposed to a wide array of parasitic diseases such as malaria, filariasis and schistosomiasis. Two new promoter variants were identified in 40 individuals. Both novel variants were heterozygous and were linked to SNP #rs3753344 (C/T), which has been described. One of the SNP variants (ss2080581728) was close to the general transcription factor site, the TATA box. We further validated these new promoter variants for their allelic gene...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Tumor necrosis factor receptor superfamily; Polymorphism; Transfection; Regulatory T cells.
Ano: 2011 URL:
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