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Interruption of recently induced immune responses by oral administration of antigen BJMBR
Conde,A.A.; Stransky,B.; Faria,A.M.C.; Vaz,N.M..
Interest in oral tolerance has been renewed in the last few years as a possibility of intervention in human autoimmune diseases. An obstacle in this direction is that, although easily induced in animals virgin of contact with the antigen, oral tolerance becomes hard to induce in previously immunized animals. The present results show that there is an early period after primary immunization in which prolonged oral exposure to the antigen may arrest ongoing immune responses. Beyond this period, oral exposures to the antigen become ineffective and may actually boost immune responses. The end of the susceptible period coincides with the emergence of free specific antibodies in serum. However, the previous administration of purified anti-ovalbumin antibodies (40...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Suppression; Antibody response; Oral tolerance; Ovalbumin.
Ano: 1998 URL:
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