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Effects of carprofen administered by different routes to control experimental uveitis in dogs Arq. Bras. Med. Vet. Zootec.
Ribeiro,A.P.; Escobar,A.; Motheo,T.F.; Sakamoto,C.A.M.; Godoy,G.S.; Costa,M.A.N.; Laus,J.L..
Efficacy of carprofen, administered by different routes, was studied in experimental uveitis in dogs. Anterior chamber paracenteses was accomplished at two different moments (M0 and M1), with a five hour interval between them. At M0 and M1, 0.2mL of aqueous humor was collected and quantitation of total protein and prostaglandin E2 (PGE2) were determined. Four groups were formed (n=8), which received carprofen at the end of M0, by the following routes: subcutaneous (GIm), subconjunctival (GII), and topical (GIII). A fourth group that received no treatment was instituted (Control). Conjunctival histopathology of the GII animals was performed. In all groups, values of protein and PGE2 significantly enhanced at M1; however, they did not significantly change...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Dog; Uveitis; Carprofen; Total protein; Prostaglandin E2.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352010000200010
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