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EEG spike source localization before and after surgery for temporal lobe epilepsy: a BOLD EEG-fMRI and independent component analysis study BJMBR
Sercheli,M.S.; Bilevicius,E.; Alessio,A.; Ozelo,H.; Pereira,F.R.S.; Rondina,J.M.; Cendes,F.; Covolan,R.J.M..
Simultaneous measurements of EEG-functional magnetic resonance imaging (fMRI) combine the high temporal resolution of EEG with the distinctive spatial resolution of fMRI. The purpose of this EEG-fMRI study was to search for hemodynamic responses (blood oxygen level-dependent - BOLD responses) associated with interictal activity in a case of right mesial temporal lobe epilepsy before and after a successful selective amygdalohippocampectomy. Therefore, the study found the epileptogenic source by this noninvasive imaging technique and compared the results after removing the atrophied hippocampus. Additionally, the present study investigated the effectiveness of two different ways of localizing epileptiform spike sources, i.e., BOLD contrast and independent...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Interictal epileptiform spike; Epilepsy surgery; EEG-fMRI; Temporal lobe epilepsy; ICA; Dipole model.
Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600017
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NAA and NAAG variation in neuronal activation during visual stimulation BJMBR
Castellano,G.; Dias,C.S.B.; Foerster,B.; Li,L.M.; Covolan,R.J.M..
N-acetyl-aspartyl-glutamate (NAAG) and its hydrolysis product N-acetyl-L-aspartate (NAA) are among the most important brain metabolites. NAA is a marker of neuron integrity and viability, while NAAG modulates glutamate release and may have a role in neuroprotection and synaptic plasticity. Investigating on a quantitative basis the role of these metabolites in brain metabolism in vivo by magnetic resonance spectroscopy (MRS) is a major challenge since the main signals of NAA and NAAG largely overlap. This is a preliminary study in which we evaluated NAA and NAAG changes during a visual stimulation experiment using functional MRS. The paradigm used consisted of a rest period (5 min and 20 s), followed by a stimulation period (10 min and 40 s) and another...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Proton magnetic resonance spectroscopy; Functional experiments; Brain activation; Brain energy metabolism; N-acetyl-L-aspartate; N-acetyl-aspartyl-glutamate.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001100006
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