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| Humblot, C.; Combourieu, B.; Väisänen, M.J.; Furet, J.P.; Delort, A.M.; Rabot, S.. |
| 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is a mutagenic/carcinogenic compound formed from meat and fish during cooking. Following ingestion, IQ is metabolized mainly by liver xenobiotic-metabolizing enzymes, but intestinal bacteria may also contribute to its biotransformation. The aim of this study was to investigate the metabolism of IQ by the human intestinal microbiota. Following incubation of IQ (200 microM) under anoxic conditions with 100-fold dilutions of stools freshly collected from three healthy volunteers, we quantified residual IQ by high-pressure liquid chromatography (HPLC) analysis and characterized the production of IQ metabolites by in situ (1)H nuclear magnetic resonance ((1)H-NMR) spectroscopic analysis of crude incubation media. In... |
| Tipo: Journal Article |
Palavras-chave: INTESTINAL MICROBIOTA; HUMAN; RAT; CARCINOGEN; MICROFLORE INTESTINALE. |
| Ano: 2005 |
URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2008cc87ce43&uri=/notices/prodinra1/2008/06/ |
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| Matheron, C.; Delort, A.M.; Gaudet, G.; Forano, E.. |
| The metabolism of glucose and cellobiose, products of cellulose hydrolysis, was investigated in four cellulolytic strains of the genus Fibrobacter: Fibrobacter succinogenes S85, 095, HM2 and Fibrobacter intestinalis NR9. In vivo 13C nuclear magnetic resonance was used to quantify the relative contribution of glucose and cellobiose to metabolite production, glycogen storage and cellodextrins synthesis in these four strains. The same features were found in all four strains of the genus Fibrobacter metabolizing simultaneously glucose and cellobiose: i) differential metabolism of glucose and cellobiose; glucose seems preferentially used for glycogen storage and energy production, while part of cellobiose seems to be diverted from glycolysis, ii) synthesis of... |
| Tipo: Journal Article |
Palavras-chave: SPECTROSMETRIE RMN; CELLOBIOSE; FIBROBACTER. |
| Ano: 1998 |
URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PUB0000031762080845&uri=/notices/prodinra1/2010/11/ |
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