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Durand, E; Helley, D; Zen, A; Dujols, C; Bruneval, P; Colliec-jouault, Sylvia; Fischer, Aurelie; Lafont, A. |
Background: Therapeutic use of unfractionated heparin and low molecular weight heparins (LMWHs) is limited by hemorrhagic adverse effects. We compared the antithrombotic effect of LMW fucoidan (LMWF) and LMWH in an experimental model. Methods: Thrombosis was induced in femoral arteries of male New Zealand White rabbits by in situ induction of endothelial apoptosis with staurosporine (10(-5) M for 30 min). Starting the day before apoptosis induction, the animals received subcutaneous LMWF (15 mg/kg), LMWH (enoxaparin 2.5 mg/kg) or saline solution (control group) twice a day for 4 days. Results: The degrees of apoptosis and endothelial denudation were similar in the 3 groups. The thrombotic score was significantly lower in the LMWF group than in the LMWH and... |
Tipo: Text |
Palavras-chave: Tissue factor; Tissue factor pathway inhibitor; Heparin; Fucoidan; Thrombosis. |
Ano: 2008 |
URL: http://archimer.ifremer.fr/doc/2008/publication-4744.pdf |
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Barnier, B; Madec, G; Penduff, T; Molines, J; Treguier, Anne-marie; Le Sommer, J; Beckmann, A; Biastoch, A; Boning, C; Dengg, J; Derval, C; Durand, E; Gulev, S; Remy, E; Talandier, Claude; Theetten, Sebastien; Maltrud, M; Mcclean, J; De Cuevas, B. |
Series of sensitivity tests were performed with a z-coordinate, global eddy-permitting (1/4 degrees) ocean/sea-ice model (the ORCA-R025 model configuration developed for the DRAKKAR project) to carefully evaluate the impact of recent state-of-the-art numerical schemes on model solutions. The combination of an energy-enstrophy conserving (EEN) scheme for momentum advection with a partial step (PS) representation of the bottom topography yields significant improvements in the mean circulation. Well known biases in the representation of western boundary currents, such as in the Atlantic the detachment of the Gulf Stream, the path of the North Atlantic Current, the location of the Confluence, and the strength of the Zapiola Eddy in the south Atlantic, are... |
Tipo: Text |
Palavras-chave: Eddy/topography interactions; Partial step topography; Momentum advection scheme; Eddy permitting ocean model; Global ocean. |
Ano: 2006 |
URL: http://archimer.ifremer.fr/doc/2006/publication-3514.pdf |
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