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| HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da.; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R.. |
| Abstract: Background: Influenza A virus (IAV) is endemic in pigs globally and co-circulation of genetically and antigenically diverse virus lineages of subtypes H1N1, H1N2 and H3N2 is a challenge for the development of effective vaccines. Virosomes are virus-like particles that mimic virus infection and have proven to be a successful vaccine platform against several animal and human viruses. Methods: This study evaluated the immunogenicity of a virosome-based influenza vaccine containing the surface glycoproteins of H1N1 pandemic, H1N2 and H3N2 in pigs. Results: A robust humoral and cellular immune response was induced against the three IAV subtypes in pigs after two vaccine doses. The influenza virosome vaccine elicited hemagglutinin-specific antibodies... |
| Tipo: Artigo de periódico |
Palavras-chave: Virosomal vaccine; Cellular immunity; Suíno; Vacina; Imunidade; Swine; Humoral immunity; Influenza A virus. |
| Ano: 2023 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1156557 |
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| BARON, L. F.; FONSECA, F. M. da.; MACIAG, S. S.; BELLAVER, F. A. V.; IBELLI, A. M. G.; MORES, M. A. Z.; ALMEIDA, G. F. de; GUTERRES, S. S.; BASTOS, A. P. A.; PAESE, K.. |
| Abstract: Coccidiosis is a disease caused by intracellular protozoan parasites of the genus Eimeria that affect the intestinal tract of poultry. However, strain resistance and drug residue in the carcass have drawn the attention of the productive sector. The nanotechnology can improve the biological effect of drugs, reducing of administered doses and toxic effects. Due to this, toltrazuril-load polymeric nanoparticles based on Eudragit® S100 (NCt) or poly-?-caprolactone (LNCt) were developed to prevent coccidiosis in broilers. Nanoformulations were produced and showed homogeneous particle diameter distribution in the nanometer range (z-average and D (4.3) < 200 nm), negative zeta potential (<?8.93 mV), drug content ~100%, and encapsulation efficiency... |
| Tipo: Artigo de periódico |
Palavras-chave: Avian coccidiosis; Eimeria spp; Polymeric nanocapsules; Eudragit® S100; Poly-E-caprolactone; Coccidiose aviária; Nanocápsulas poliméricas; Toltrazuril. |
| Ano: 2022 |
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1140277 |
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