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Registros recuperados: 21
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2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study IPB - Escola Superior Agrária
Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda.
Xanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. The inclusion of aryl groups has only been reported for a few synthetic derivatives, the 2,3-diaryl moiety being recently introduced by our group. Xanthones are endowed with a broad spectrum of biological activities, many of them related to their antioxidant ability, including the scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating effects. Considering the interesting and promising antioxidant activities present in compounds derived from the xanthone core, the main...
Tipo: Article Palavras-chave: 2; 3-Diarylxanthones Reactive oxygen species Reactive nitrogen species Scavenging activity Antioxidant activity.
Ano: 2010 URL: http://hdl.handle.net/10198/3241
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2-Styrylchromones as novel inhibitors of xanthine oxidase. A structure-activity study IPB - Escola Superior Agrária
Fernandes, Eduarda; Carvalho, Félix; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Bastos, Maria de Lourdes.
The purpose of this study was the evaluation of the xanthine oxidase (XO) inhibition produced by some synthetic 2-styrylchromones. Ten polyhydroxylated derivatives with several substitution patterns were synthesised, and these and a positive control, allopurinol, were tested for their effects on XO activity by measuring the formation of uric acid from xanthine. The synthesised 2-styrylchromones inhibited xanthine oxidase in a concentration-dependent and non-competitive manner. Some IC50 values found were as low as 0.55mM, which, by comparison with the IC50 found for allopurinol (5.43 mM), indicates promising new inhibitors. Those 2-styrylchromones found to be potent XO inhibitors should be further evaluated as potential agents for the treatment of...
Tipo: Article Palavras-chave: 2-styrylchromones; Allopurinol; Benzopyrone; Xanthine oxidase inhibition.
Ano: 2002 URL: http://hdl.handle.net/10198/3931
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2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Lima, José Costa.
2-Styrylchromones are a small group of naturally occurring chromones, vinylogues of flavones (2-phenylchromones). Natural and synthetic 2-styrylchromones have been tested in different biological systems, showing activities with potential therapeutic applications. In particular, the potential and hitherto understudied antioxidant behavior of these compounds has been raised as a matter of interest. Thus the present work consisted in the study of the in vitro scavenging activities for reactive oxygen species (ROS) and reactive nitrogen species (RNS) of various 2-styrylchromone derivatives and structurally similar flavonoids. Some of the studied 2-styrylchromones proved to be extremely efficient scavengers of the different ROS and RNS, showing, in some cases,...
Tipo: Article Palavras-chave: 2-Styrylchromones; Reactive oxygen species; Reactive nitrogen species; Scavenging activity; Antioxidant activity.
Ano: 2007 URL: http://hdl.handle.net/10198/3922
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Anti-inflammatory potencial of 2-Styrylchromones regarding their interference with arachidonic acid metabolic pathways IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Lima, José Costa.
Tipo: ConferenceObject
Ano: 2008 URL: http://hdl.handle.net/10198/3375
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Anti-inflammatory potential of 2-styrylchromones regarding their interference with arachidonic acid metabolic pathways IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Lima, José Costa.
Cyclooxygenases (COXs) are the key enzymes in the biosynthesis of prostanoids. COX-1 is a constitutive enzyme while the expression of COX-2 is highly stimulated in the event of inflammatory processes, leading to the production of large amounts of prostaglandins (PGs), in particular PGE2 and PGI2, which are pro-inflammatory mediators. Lipoxygenases (LOXs) are enzymes that produce hydroxy acids and leukotrienes (LTs). 5-LOX metabolizes arachidonic acid to yield, among other products, LTB4, a potent chemoattractantmediator of inflammation. The aim of the present work was to evaluate the anti-inflammatory potential of 2-styrylchromones (2-SC), a chemical family of oxygen heterocyclic compounds, vinylogues of flavones (2-phenylchromones), by studying their...
Tipo: Article Palavras-chave: 2-Styrylchromones; Cyclooxygenase; 5-Lipoxigenase; Leukotriene B4; Dual inhibitors; Inflammation.
Ano: 2009 URL: http://hdl.handle.net/10198/3919
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Cyclic voltammetric analysis of 2-styrylchromones IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Garcia, M. Beatriz; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Lima, José Costa.
Tipo: ConferenceObject
Ano: 2008 URL: http://hdl.handle.net/10198/3355
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Cyclic voltammetric analysis of 2-styrylchromones: Relationship with the antioxidant activity IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Garcia, M. Beatriz; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Lima, José Costa.
2-Styrylchromones (2-SC) are a chemical family of oxygen heterocyclic compounds, vinylogues of flavones (2-phenylchromones), whose occurrence in nature has been reported. Recently, several 2-SC derivatives were demonstrated to have antioxidant properties, namely, xanthine oxidase inhibition, hepatoprotection against pro-oxidant agents in cellular and non-cellular systems and scavenging activity against reactive oxygen and reactive nitrogen species (ROS and RNS). Considering these antioxidant properties, it may be hypothesised that the electrochemical redox behaviour of 2-SC contributes significantly to their activity. To test this hypothesis, the electrochemical behaviour of different 2-SC was studied, together with a number of flavonoids with well-known...
Tipo: Article Palavras-chave: 2-Styrylchromones; Cyclic voltammetry; Oxidation mechanism; Scavenging activity; Reactive oxygen species; Reactive nitrogen species.
Ano: 2008 URL: http://hdl.handle.net/10198/4011
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Hepatoprotective activity of 2-styrylchromone derivatives against the pro-oxidant hepatotoxic effect elicited by tert-butylhydroperoxide in freshy isolated rat hepatocytes IPB - Escola Superior Agrária
Fernandes, Eduarda; Carvalho, M.; Carvalho, Félix; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Bastos, Maria de Lourdes.
Tipo: ConferenceObject
Ano: 2003 URL: http://hdl.handle.net/10198/3496
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Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes IPB - Escola Superior Agrária
Fernandes, Eduarda; Carvalho, M.; Carvalho, Félix; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Bastos, Maria de Lourdes.
2-Styrylchromones are a novel class of chromones, vinylogues of flavones (2-phenylchromones), which have recently been found in nature. The best described property of almost every group of flavones and other flavonoids, especially the hydroxylated derivatives, is their capacity to act as antioxidants. Indeed there is a widely accepted view that the positive health effects of flavones are due to their antioxidant activity. As oxidative stress is a main cause of liver toxicity induced by several hepatotoxicants, agents with the ability to protect the liver against reactive pro-oxidant species may be therapeutically useful. The present study evaluated the possible protective activity of six new synthetic polyhydroxylated 2-styrylchromone derivatives against...
Tipo: Article Palavras-chave: 2-Styrylchromones; Tert-Butylhydroperoxide; Hepatoprotective activity; Freshly isolated rat hepatocytes.
Ano: 2003 URL: http://hdl.handle.net/10198/3977
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Incorporation of 2-styrylchromones in liposomes: preliminaries studies IPB - Escola Superior Agrária
Carlos, M.; Almeida, M.; Fernandes, Eduarda; Lima, José Costa; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Gaspar, R.; Corvo, M.L..
Tipo: ConferenceObject
Ano: 2008 URL: http://hdl.handle.net/10198/3353
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Inhibition of Leukotriene B4 production in human Neutrophils by 2-Styrylchromones IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Freitas, Marisa; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Lima, José Costa.
Tipo: ConferenceObject
Ano: 2007 URL: http://hdl.handle.net/10198/3384
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Interactions of 2-Styrylchromones with pro-inflamatory enzymes and oxidative species IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Lima, José Costa.
Tipo: ConferenceObject
Ano: 2007 URL: http://hdl.handle.net/10198/3431
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Metodologias para avaliar a actividade captadora de espécies reactivas de oxigénio e de azoto envolvidas no processo inflamatório IPB - Escola Superior Agrária
Gomes, Ana; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Fernandes, Eduarda; Lima, José Costa.
As espécies reactivas de oxigénio (ERO) e de azoto (ERA) estão envolvidas nos processos inflamatórios, nomeadamente através da sua produção c libertação pelos neutrófilos. Apesar da produção dessas espécies fazer pal1e dos mecanismos de defesa inata do organismo, por vezes esta torna-se descontrolada, com efeitos deletérios para os tecidos. Na verdade, foi já sugerido em diferentes estudos que a actividade anti-inflamatória de fármacos da classe dos anti-inflamatórios não esteróides se deve, cm parte, à sua capacidade de interferir nas reacções mediadas por ERO e ERA. Assim sendo, o desenvolvimento e aplicação de métodos que pe1111itam avaliar a actividade captadora destas espécies assume um importante papel no estudo de novas moléculas com potencial...
Tipo: ConferenceObject Palavras-chave: 2-Estirilcromonas; Especies reactivas de oxigénio; Espécies reactivas de azoto.
Ano: 2010 URL: http://hdl.handle.net/10198/3980
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NDPO2 as a selective generator of 1o2 used in the scavenging activity assay of 2,3-diarylxanthones IPB - Escola Superior Agrária
Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda.
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3495
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Nitric oxide and superoxide radical scavenging of 2-Styrylchromones IPB - Escola Superior Agrária
Fernandes, Eduarda; Gomes, Ana; Moutinho, L.; Costa, D.; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Lima, José Costa.
Tipo: ConferenceObject
Ano: 2005 URL: http://hdl.handle.net/10198/3490
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Novel 2-Styrylchromones with high anti-inflammatory potencial through prevention of LTB4 production by human leukocytes, inhibition of COX-1 activity and scavenging of ROS and RNS IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Lima, José Costa.
Tipo: ConferenceObject
Ano: 2008 URL: http://hdl.handle.net/10198/3352
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Potent Inhibition of Xanthine Oxidase by Novel 2-Styrylchromones IPB - Escola Superior Agrária
Fernandes, Eduarda; Carvalho, Félix; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Bastos, Maria de Lourdes.
Tipo: ConferenceObject
Ano: 2001 URL: http://hdl.handle.net/10198/3796
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ROS and RNS Scavenging Activity by 2,3-Diarylxanthones IPB - Escola Superior Agrária
Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda.
Xanthones constitute an important class of heterocyclic compounds that commonly occur in nature. The inclusion of aryl groups has only been reported for a few synthetic derivatives, being the 2,3-diaryl moiety recently introduced by our group.~ The pharmacological properties of both natural and synthetic xanthones have attracted great attention namely as antioxidant, anti-allergic, anti-inflammatory, antimalarial and antitumour protectors. The antioxidant activity deserves special mention, considering the potent scavenging activity for reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating activity already reported for some compounds bearing the xanthone scaffold. Thus, the main goal of this work was to evaluate the...
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3797
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Singlet oxygen scavenging activity by 2-Styrylchromones IPB - Escola Superior Agrária
Gomes, Ana; Fernandes, Eduarda; Silva, Artur; Santos, Clementina M.M.; Pinto, Diana; Cavaleiro, José; Lima, José Costa.
Tipo: ConferenceObject
Ano: 2006 URL: http://hdl.handle.net/10198/3428
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The 2-styrylchromone structure is an effective scaffold for the development of new inibitors of the nf-kb pathway IPB - Escola Superior Agrária
Gomes, Ana; Freitas, Marisa; Capela, J.; Silva, Artur; Pinto, Diana; Santos, Clementina M.M.; Cavaleiro, José; Fernandes, Eduarda; Lima, José Costa.
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3473
Registros recuperados: 21
Primeira ... 12 ... Última
 

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