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Characterization of angiotensin-converting enzymes 1 and 2 in the soleus and plantaris muscles of rats 56
Fernandes,T.; Hashimoto,N.Y.; Oliveira,E.M..
Angiotensin-converting enzymes 1 (ACE1) and 2 (ACE2) are key enzymes of the renin-angiotensin system, which act antagonistically to regulate the levels of angiotensin II (Ang II) and Ang-(1-7). Considerable data show that ACE1 acts on normal skeletal muscle functions and architecture. However, little is known about ACE1 levels in muscles with different fiber compositions. Furthermore, ACE2 levels in skeletal muscle are not known. Therefore, the purpose of this study was to characterize protein expression and ACE1 and ACE2 activities in the soleus and plantaris muscles. Eight-week-old female Wistar rats (N = 8) were killed by decapitation and the muscle tissues harvested for biochemical and molecular analyses. ACE1 and ACE2 activities were investigated by a...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Renin-angiotensin system; ACE1; ACE2; Rat skeletal muscle.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000900005
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Eccentric and concentric cardiac hypertrophy induced by exercise training: microRNAs and molecular determinants 56
Fernandes,T.; Soci,U.P.R.; Oliveira,E.M..
Among the molecular, biochemical and cellular processes that orchestrate the development of the different phenotypes of cardiac hypertrophy in response to physiological stimuli or pathological insults, the specific contribution of exercise training has recently become appreciated. Physiological cardiac hypertrophy involves complex cardiac remodeling that occurs as an adaptive response to static or dynamic chronic exercise, but the stimuli and molecular mechanisms underlying transduction of the hemodynamic overload into myocardial growth are poorly understood. This review summarizes the physiological stimuli that induce concentric and eccentric physiological hypertrophy, and discusses the molecular mechanisms, sarcomeric organization, and signaling pathway...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exercise training; Cardiac hypertrophy; Renin-angiotensin system; AT1 receptor; Akt; MicroRNAs.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900003
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