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| Registros recuperados: 10 | |
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| Miranda,Janisse Crestani de; Martins,Tércio Elyan Azevedo; Veiga,Francisco; Ferraz,Humberto Gomes. |
| Cyclodextrins (CDs) are cyclic oligosaccharides composed of D-glucopyranoside units linked by glycosidic bonds. Their main property is the ability to modify the physicochemical and biological characteristics of low-soluble drugs through the formation of drug:CD inclusion complexes. Inclusion complexation requires that host molecules fit completely or partially within the CD cavity. This adjustment is directly related to the physicochemical properties of the guest and host molecules, easy accommodation of guest molecules within the CD cavity, stoichiometry, therapeutic dose, and toxicity. However, dosage forms may achieve a high volume, depending on the amount of CD required. Thus, it is necessary to increase solubilization efficiency in order to use... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cyclodextrins; Ternary complexes; Drugs/complexation; Water-soluble polymers/use; Drugs/solubility; Inclusion complexe. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400003 |
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| Consiglieri,Vladi Olga; Mourão,Samanta; Sampaio,Mauricio; Granizo,Patricia; Garcia,Pedro; Martinello,Valeska; Spricigo,Rodrigo; Ferraz,Humberto Gomes. |
| The aim of this work was to improve fluconazole flowability by wet granulation and to study the effect of granulation on drug dissolution from tablets and capsules. Fluconazole was submitted to a process of wet granulation in a high-speed granulator using Plasdone® K29/32 or K90. Flow properties of granules and dissolution profiles for tablets and capsules produced with them were determined. Fluconazole granules demonstrated better flowability, calculated by angle of repose and compressibility index data, compared with powder. Additionally, it was observed that the granulation process improved the dissolution efficiency (ED) of fluconazole from tablets and capsules, which could also suggest an increase in bioavailability. Higher dissolution efficiencies... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fluconazole/flowability; Tablets/dissolution; Capsules/dissolution; Plasdone. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100013 |
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| Rodrigues,Leticia Norma Carpentieri; Issa,Michelle Georges; Asbahr,Ana Carolina Cavassin; Silva,Marco Aurélio Carvalho; Ferraz,Humberto Gomes. |
| The combined effect of hydroxypropyl-β-cyclodextrin (HPβCD) and polyvinylpyrrolidone (PVP) or sodium carboxymethylcellulose (CMC) on the solubility of pyrimethamine (PYR) was studied. Equimolar PYR-HPβCD solid systems, in the presence or the absence of 0.25% (w/v) PVP or 0.10% (w/v) CMC were prepared by coevaporation or freeze-drying, and characterized by differential scanning calorimetry, X-ray diffraction analysis and dissolution profile. Phase-solubility analysis was used to investigate the interactions in aqueous solution between PYR and HPβCD, in the absence or presence of polymers, which showed a linear increase of PYR solubility depending on the concentration of HPβCD. The presence of polymer did not alter the stoichiometry of the complexes. DSC... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pyrimethamine; HPβCD; Inclusion complexes. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000500014 |
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| Issa,Michele Georges; Souza,Natalia Vieira de; Duque,Marcelo Dutra; Ferraz,Humberto Gomes. |
| ABSTRACT The search for new pharmaceutical dosage forms and different drug delivery systems already used in therapeutics is a global trend, serving as an opportunity to expand the portfolio for the pharmaceutical industry. In this context, multiparticulate systems, such as pellets, granules, and minitablets, represent an attractive alternative, given the range of possibilities they provide. Among the methods used in the production of these systems, we highlight the process of extrusion-spheronization for pellet manufacture, wet granulation and hot-melt extrusion for the obtention of granules, and direct compression for minitablets. Although highly versatile, depending on the technology chosen, many processes and formulation variables can influence the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Multiparticulate systems/physical characterization; Pellets; Granules; Minitablets. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400403 |
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| Issa,Michele Georges; Pessole,Letícia; Takahashi,Andrea Ikeda; Andréo Filho,Newton; Ferraz,Humberto Gomes. |
| With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylmethylcellulose and methylcellulose, and we evaluated their different binding properties. The pellets were obtained by the extrusion/spheronization process and were subsequently subjected to fluid bed drying. In order to assess drug delivery, the United States Pharmacopeia (USP) apparatus 3 (Bio-Dis) was employed, in conjunction with the method described by the same pharmacopeia for the dissolution of paracetamol tablets (apparatus 1). The pellets were also evaluated for granulometry, friability, true density and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Binders/evaluation; Pellets/dissolution profile; Pellets/physicochemical characteristics; Extrusion/spheronization process; Drug delivery/evaluation. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000300004 |
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| Giorgetti,Leandro; Issa,Michele Georges; Ferraz,Humberto Gomes. |
| The aim of this study was to evaluate the effect of dissolution medium, rotation speed and compaction pressure on the intrinsic dissolution rate (IDR) of the antihypertensive drug amlodipine besylate, using the rotating disk method. Accordingly, a fractional factorial design (33-1) was used, employing dissolution media (water, phosphate buffer pH 6.8 and HCl 0.1 M), rotation speed (50, 75 and 100 rpm), and compaction pressure (1000, 1500 and 2000 psi) as independent variables. The assays were randomized and statistically compared using the Statistica(r) 11 software program. Significance testing (ANOVA) indicated that the dissolution medium had a considerable impact on the IDR of amlodipine besylate. Analysis of the linear and quadratic components of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Amlodipine besylate/intrinsic dissolution; Biopharmaceutical classification system; Drugs/experimental design; Antihypertensive drugs/Amlodipine besylate. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300513 |
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| Registros recuperados: 10 | |
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