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| Freitas,S.C.M.P.; Tavares,E.R.; Silva,B.M.O.; Meneghini,B.C.; Kalil-Filho,R.; Maranhão,R.C.. |
| Particles are usually polydispersed and size is an important feature for lipid-based drug delivery systems in order to optimize cell-particle interactions as to pharmacologic action and toxicity. Lipid nanoparticles (LDE) with composition similar to that of low-density lipoprotein carrying paclitaxel were shown to markedly reduce atherosclerosis lesions induced in rabbits by cholesterol feeding. The aim of this study was to test whether two LDE fractions, one with small (20–60 nm) and the other with large (60–100 nm) particles, had different actions on the atherosclerotic lesions. The two LDE-paclitaxel fractions, prepared by microfluidization, were separated by density gradient ultracentrifugation and injected (4 mg/body weight, intravenously once a week)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Solid lipid nanoparticles; Drug targeting; Paclitaxel; Atherosclerosis; Particle size. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000300612 |
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