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	Provedor de dados BJPS (1) Autor Gaikwad,Naresh Janardan (1) Patil,Moreshwar Pandharinath (1) Palavra-chave Gliclazide (1) In vitro dissolution (1) Polyethylene glycol 6000 (1) Solid dispersion (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2011 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Characterization of gliclazide-polyethylene glycol solid dispersion and its effect on dissolution BJPS Patil,Moreshwar Pandharinath; Gaikwad,Naresh Janardan. The present study was initiated with the objective of studying the in vitro dissolution behavior of gliclazide from its solid dispersion with polyethylene glycol 6000. In this work, a solid dispersion of gliclazide with polyethylene glycol was prepared by the fusion method. In vitro dissolution study of gliclazide, its physical mixture and solid dispersion were carried out to demonstrate the effect of PEG 6000. Analytical techniques of FT-IR spectroscopy, differential scanning calorimetry and X-ray diffractometry were used to characterize the drug in the physical mixtures and solid dispersions. The dissolution studies of solid dispersion and physical mixture showed greater improvement compared to that of the pure drug. The mechanisms for increased... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gliclazide; Polyethylene glycol 6000; Solid dispersion; In vitro dissolution. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000100020 Registros recuperados: 1 Primeira ... 1 ... Última

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