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	Provedor de dados BJPS (1) Autor Bhalekar,Mangesh Ramesh (1) Gambhire,Makarand Suresh (1) Gambhire,Vaishali Makarand (1) Palavra-chave 3² factorial design (1) Dithranol (1) Homogenization (1) Solid lipid nanoparticles (1) Ultrasonication (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2011 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Statistical optimization of dithranol-loaded solid lipid nanoparticles using factorial design BJPS Gambhire,Makarand Suresh; Bhalekar,Mangesh Ramesh; Gambhire,Vaishali Makarand. This study describes a 3² full factorial experimental design to optimize the formulation of dithranol (DTH) loaded solid lipid nanoparticles (SLN) by the pre-emulsion ultrasonication method. The variables drug: lipid ratio and sonication time were studied at three levels and arranged in a 3² factorial design to study the influence on the response variables particle size and % entrapment efficiency (%EE). From the statistical analysis of data polynomial equations were generated. The particle size and %EE for the 9 batches (R1 to R9) showed a wide variation of 219-348 nm and 51.33- 71.80 %, respectively. The physical characteristics of DTH-loaded SLN were evaluated using a particle size analyzer, differential scanning calorimetry and X-ray diffraction. The... Tipo: Info:eu-repo/semantics/article Palavras-chave: Solid lipid nanoparticles; Homogenization; Ultrasonication; 3² factorial design; Dithranol. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300008 Registros recuperados: 1 Primeira ... 1 ... Última

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