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Dietary sodium intake induced myenteric neuron hypertrophy in Wistar rats 56
De Souza,R.R.; Gama,E.F.; Silva,R.D.A.; Heimann,J.C.; Maifrino,L.B.M.; Liberti,E.A..
In the present study we investigated the effect of salt intake on myenteric neuron size of the colon of adult male Wistar rats. The animals were placed on either a high-salt (HS; 8%; 12 animals) or a low-salt diet (LS; 0.15%; 12 animals) for 15 or 52 weeks and blood pressure was measured. The sizes of myenteric neurons of the distal colon from both groups were measured. No difference in neuron size was observed between the HS and LS groups after 15 weeks. After 52 weeks on HS, neuron size was increased (P<0.005) when compared with the LS group. The rats also presented hypertension, which was significantly different at 52 weeks (142 ± 11 vs 119 ± 7 mmHg). These results suggest that a long time on an HS diet can significantly increase myenteric nerve...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Myenteric plexus; Neuron size; Cell growth; Sodium intake.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000700017
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Lycopene and ß-carotene protect in vivo iron-induced oxidative stress damage in rat prostate 56
Matos,H.R.; Marques,S.A.; Gomes,O.F.; Silva,A.A.; Heimann,J.C.; Di Mascio,P.; Medeiros,M.H.G..
It has been suggested that iron overload may be carcinogenic. In the present study, we evaluated the effect of plasma and prostate carotenoid concentration on oxidative DNA damage in 12-week-old Wistar rats treated with intraperitoneal (ip) ferric nitrilotriacetate (Fe-NTA) (10 mg Fe/kg). Plasma ß-carotene and lycopene concentrations were measured as a function of time after ip injection of carotenoids (10 mg kg-1 day-1 ß-carotene or lycopene) in rats. The highest total plasma concentration was reached 3 and 6 h after ip injection of lycopene or ß-carotene, respectively. After 5 days of carotenoid treatment, lycopene and ß-carotene were present in the 0.10-0.51 nmol/g wet tissue range in the prostate. Using a sensitive method to detected...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Lycopene ß-carotene DNA damage 8-oxo-7; 8-dihydro- 2'-deoxyguanosine Ferric nitrilotriacetate Prostate cancer.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000200006
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