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| Yi,C.; Cao,Y.; Wang,S.R.; Xu,Y.Z.; Huang,H.; Cui,Y.X.; Huang,Y.. |
| The objective of the present study was to investigate the effects of recombinant human growth hormone (rhGH) on the intestinal mucosa barrier of septic rats and explore its possible mechanism. Female Sprague-Dawley rats were randomized into three groups: control, Escherichia coli-induced sepsis (S) and treatment (T) groups. Groups S and T were subdivided into subgroups 1d and 3d, respectively. Expression of liver insulin-like growth factor-1 (IGF-1) mRNA, Bcl-2 and Bax protein levels and the intestinal Bax/Bcl-2 ratio, and plasma GH and IGF-1 levels were determined. Histological examination of the intestine was performed and bacterial translocation was determined. rhGH significantly attenuated intestinal mucosal injuries and bacterial translocation in... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Intestinal mucosa barrier; Growth hormone; Sepsis; Insulin-like growth factor-1; Apoptosis. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100006 |
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| Qian,W.F.; Guan,W.X.; Gao,Y.; Tan,J.F.; Qiao,Z.M.; Huang,H.; Xia,C.L.. |
| In order to investigate signal transduction and activation of transcription 3 (STAT3) signaling on angiogenesis in colorectal carcinoma (CRC) after inhibiting STAT3 expression, we constructed the HT-29-shSTAT3 cell line by lentivirus-mediated RNAi. Cell growth was assessed with MTT and the cell cycle distribution by flow cytometry. CRC nude mouse models were established and tumor growth was monitored periodically. On day 30, all mice were killed and tumor tissues were removed. Microvessel density (MVD) was determined according to CD34-positive staining. The expression of vascular endothelial growth factor A (VEGFA), matrix metalloproteinase-2 (MMP2) and basic fibroblast growth factor (FGF2) was monitored by quantitative real-time PCR and Western blot... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: STAT3; RNA interference; Colorectal carcinoma; Angiogenesis; VEGFA; MMP2; FGF2. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001200005 |
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| Scarpelini,S.; Rhind,S.G.; Nascimento,B.; Tien,H.; Shek,P.N.; Peng,H.T.; Huang,H.; Pinto,R.; Speers,V.; Reis,M.; Rizoli,S.B.. |
| Thromboelastography (TEG®) provides a functional evaluation of coagulation. It has characteristics of an ideal coagulation test for trauma, but is not frequently used, partially due to lack of both standardized techniques and normal values. We determined normal values for our population, compared them to those of the manufacturer and evaluated the effect of gender, age, blood type, and ethnicity. The technique was standardized using citrated blood, kaolin and was performed on a Haemoscope 5000 device. Volunteers were interviewed and excluded if pregnant, on anticoagulants or having a bleeding disorder. The TEG® parameters analyzed were R, K, α, MA, LY30, and coagulation index. All volunteers outside the manufacturer’s normal range underwent extensive... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Coagulation; Thromboelastography; Normal values. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001200015 |
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