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A semi-automatic computerized method to measure baroreflex-mediated heart rate responses that reduces interobserver variability 56
Soares,P.P.S.; Ushizima,M.R.; Krieger,E.M.; Irigoyen,M.C.C..
Arterial baroreflex sensitivity estimated by pharmacological impulse stimuli depends on intrinsic signal variability and usually a subjective choice of blood pressure (BP) and heart rate (HR) values. We propose a semi-automatic method to estimate cardiovascular reflex sensitivity to bolus infusions of phenylephrine and nitroprusside. Beat-to-beat BP and HR time series for male Wistar rats (N = 13) were obtained from the digitized signal (sample frequency = 2 kHz) and analyzed by the proposed method (PRM) developed in Matlab language. In the PRM, time series were low-pass filtered with zero-phase distortion (3rd order Butterworth used in the forward and reverse direction) and presented graphically, and parameters were selected interactively. Differences...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Baroreflex sensitivity; Heart rate; Blood pressure; Phenylephrine; Nitroprusside.
Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000600018
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Baroreflex control of sympathetic activity in experimental hypertension 56
Irigoyen,M.C.C.; Krieger,E.M..
The arterial baroreceptor reflex system is one of the most powerful and rapidly acting mechanisms for controlling arterial pressure. The purpose of the present review is to discuss data relating sympathetic activity to the baroreflex control of arterial pressure in two different experimental models: neurogenic hypertension by sinoaortic denervation (SAD) and high-renin hypertension by total aortic ligation between the renal arteries in the rat. SAD depresses baroreflex regulation of renal sympathetic activity in both the acute and chronic phases. However, increased sympathetic activity (100%) was found only in the acute phase of sinoaortic denervation. In the chronic phase of SAD average discharge normalized but the pattern of discharges was different from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Baroreflex; Sympathetic activity; Sinoaortic denervation; High-renin hypertension.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900015
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Comparison of three methods for the determination of baroreflex sensitivity in conscious rats 56
Farah,V.M.A.; Moreira,E.D.; Pires,M.D.; Irigoyen,M.C.C.; Krieger,E.M..
Baroreflex sensitivity was studied in the same group of conscious rats using vasoactive drugs (phenylephrine and sodium nitroprusside) administered by three different approaches: 1) bolus injection, 2) steady-state (blood pressure (BP) changes produced in steps), 3) ramp infusion (30 s, brief infusion). The heart rate (HR) responses were evaluated by the mean index (mean ratio of all HR changes and mean arterial pressure (MAP) changes), by linear regression and by the logistic method (maximum gain of the sigmoid curve by a logistic function). The experiments were performed on three consecutive days. Basal MAP and resting HR were similar on all days of the study. Bradycardic responses evaluated by the mean index (-1.5 ± 0.2, -2.1 ± 0.2 and -1.6 ± 0.2...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Baroreflex; Baroreceptor; Bradycardia; Tachycardia.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300018
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