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	Provedor de dados BJMBR (2) Autor Hong,S. (2) Kim,C.Y. (2) Seong,G.J. (2) Hara,H. (1) Hyakkoku,K. (1) Iizuka,Y. (1) Lee,J.E. (1) Shimazawa,M. (1) Yang,W.I. (1) Mais... Palavra-chave Agmatine (2) Neuroprotection (2) Apoptosis (1) Ischemia (1) Oxidative stress (1) Retina (1) Retinal ganglion cell (1) Mais... Tipo do documento Info:eu-repo/semantics/other (2) Ano 2012 (1) 2010 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Protective mechanism of agmatine pretreatment on RGC-5 cells injured by oxidative stress BJMBR Iizuka,Y.; Hong,S.; Kim,C.Y.; Yang,W.I.; Lee,J.E.; Seong,G.J.. Agmatine has neuroprotective effects on retinal ganglion cells (RGCs) as well as cortical and spinal neurons. It protects RGCs from oxidative stress even when it is not present at the time of injury. As agmatine has high affinity for various cellular receptors, we assessed protective mechanisms of agmatine using transformed RGCs (RGC-5 cell line). Differentiated RGC-5 cells were pretreated with 100 μM agmatine and consecutively exposed to 1.0 mM hydrogen peroxide (H2O2). Cell viability was determined by measuring lactate dehydrogenase (LDH), and the effects of selective alpha 2-adrenergic receptor antagonist yohimbine (0-500 nM) and N-methyl-D-aspartic acid (NMDA) receptor agonist NMDA (0-100 µM) were evaluated. Agmatine’s protective effect was compared to... Tipo: Info:eu-repo/semantics/other Palavras-chave: Agmatine; Neuroprotection; Oxidative stress; Retinal ganglion cell. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000400006 Retinal protective effects of topically administered agmatine on ischemic ocular injury caused by transient occlusion of the ophthalmic artery BJMBR Hong,S.; Hara,H.; Shimazawa,M.; Hyakkoku,K.; Kim,C.Y.; Seong,G.J.. Agmatine, an endogenous polyamine and putative neuromodulator, is known to have neuroprotective effects on various neurons in the central nervous system. We determined whether or not topically administered agmatine could reduce ischemic retinal injury. Transient ocular ischemia was achieved by intraluminal occlusion of the middle cerebral artery of ddY mice (30-35 g) for 2 h, which is known to also induce occlusion of the ophthalmic artery. In the agmatine group (N = 6), a 1.0 mM agmatine-containing ophthalmic solution was administered four times daily for 2 weeks before occlusion. In the control group (N = 6), a 0.1% hyaluronic acid ophthalmic solution was instilled at the same times. At 22 h after reperfusion, the eyeballs were enucleated and the retinal... Tipo: Info:eu-repo/semantics/other Palavras-chave: Agmatine; Apoptosis; Ischemia; Neuroprotection; Retina. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000300005 Registros recuperados: 2 Primeira ... 1 ... Última

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