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Effects of septal cholinergic lesion on rat exploratory behavior in an open-field 56
Lamprea,M.R.; Cardenas,F.P.; Silveira,R.; Walsh,T.J.; Morato,S..
The medial septum participates in the modulation of exploratory behavior triggered by novelty. Also, selective lesions of the cholinergic component of the septohippocampal system alter the habituation of rats to an elevated plus-maze without modifying anxiety indices. We investigated the effects of the intraseptal injection of the cholinergic immunotoxin 192 IgG-saporin (SAP) on the behavior of rats in an open-field. Thirty-nine male Wistar rats (weight: 194-230 g) were divided into three groups, non-injected controls and rats injected with either saline (0.5 µl) or SAP (237.5 ng/0.5 µl). Twelve days after surgery, the animals were placed in a square open-field (120 cm) and allowed to freely explore for 5 min. After the test, the rats were killed by...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Exploratory behavior; Open-field; Cholinergic immunotoxin; Medial septum; Saporin.
Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000200011
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Thigmotactic responses in an open-field 56
Lamprea,M.R.; Cardenas,F.P.; Setem,J; Morato,S..
The goal of the present study was to investigate the role of thigmotaxis (the tendency to remain close to vertical surfaces) in rat exploratory behavior in an open-field. Thigmotaxis was investigated in a parametric way, using 24 experimentally adult naive male Wistar rats (210-230 g). Exploratory behavior was studied in an open-field (N = 12) in 5-min sessions and behavior was analyzed in terms of where it occurred: in areas surrounded by two, one, or no walls. Another group of rats (N = 12) was studied in an open-field with blocks placed near two of the corners so as to make these corner areas surrounded by three walls. The floor of the open-fields was divided into 20-cm squares in order to locate the exact place of occurrence of each behavior. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Exploratory behavior; Thigmotaxis; Open-field; Rearing behavior; Grooming; Locomotion.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200010
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