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An amphioxus orthologue of the estrogen receptor that does not bind estradiol: Insights into estrogen receptor evolution Inra
Paris, M.; Pettersson, K.; Schubert, M.; Bertrand, S.; Pongratz, I.; Escriva, H.; Laudet, V..
Background: The origin of nuclear receptors (NRs) and the question whether the ancestral NR was a liganded or an unliganded transcription factor has been recently debated. To obtain insight into the evolution of the ligand binding ability of estrogen receptors (ER), we comparatively characterized the ER from the protochordate amphioxus (Branchiostoma floridae), and the ER from lamprey (Petromyzon marinus), a basal vertebrate.Results: Extensive phylogenetic studies as well as signature analysis allowed us to confirm that the amphioxus ER (amphiER) and the lamprey ER (lampER) belong to the ER group. LampER behaves as a "classical" vertebrate ER, as it binds to specific DNA Estrogen Responsive Elements (EREs), and is activated by estradiol (E2), the classical...
Tipo: Journal Article Palavras-chave: RÉCEPTEUR ŒSTROGÈNE; ÉVOLUTION MOLÉCULAIRE; ESTRADIOL; PETROMYZON; ÉVOLUTION; RÉCEPTEUR STÉROÏDE; PHYLOGÉNIE; AMPHIOXUS; LAMPROIE.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009dfd9d605&uri=/notices/prodinra1/2009/12/
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Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes Inra
Robinson-Rechavi, M.; Maina, C.V.; Gissendanner, C.R.; Laudet, V.; Sluder, A..
The nuclear receptor superfamily expanded in at least two episodes: one early in metazoan evolution, the second within the vertebrate lineage. An exception to this pattern is the genome of the nematode Caenorhabditis elegans, which encodes more than 270 nuclear receptors, most of them highly divergent. We generated 128 cDNA sequences for 76 C. elegans nuclear receptors, confirming that these are active genes. Among these numerous receptors are 13 orthologues of nuclear receptors found in arthropods and/or vertebrates. We show that the supplementary nuclear receptors (supnrs) originated from an explosive burst of duplications of a unique orphan receptor, HNF4. This origin has specific implications for the role of ligand binding in the function and evolution...
Tipo: Journal Article Palavras-chave: NEMATODE; RECEPTEUR NUCLEAIRE; EVOLUTION; POLYGENIE DEVELOPMENT; DUPLICATION; ENDOCRINOLOGY; EVOLUTIONARY RATE; PHYLOGENY; TRANSCRIPTION FACTOR.
Ano: 2005 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20089c9e48c5&uri=/notices/prodinra1/2010/11/
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Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development Inra
Pantalacci, S.; Prochazka, J.; Martin, A.; Rothova, M.; Lambert, A.; Bernard, L.; Charles, C.; Viriot, L.; Peterkova, R.; Laudet, V..
Background: The development of the secondary palate has been a main topic in craniofacial research, as its failure results in cleft palate, one of the most common birth defects in human. Nevertheless, palatal rugae (or rugae palatinae), which are transversal ridges developing on the secondary palate, received little attention. However, rugae could be useful as landmarks to monitor anterior/posterior (A/P) palatal growth, and they provide a simple model of mesenchymal-epithelial structures arranged in a serial pattern.Results: We first determined in which order the nine mouse rugae appear during development. Our results revealed a reiterative process, which is coupled with A/P growth of palatal shelves, and by which rugae 3 to 7b are sequentially...
Tipo: Journal Article Palavras-chave: FENTE PALATINE; POLARITÉ DÉVELOPPEMENT; DÉVELOPPEMENT EMBRYONNAIRE.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200945f42261&uri=/notices/prodinra1/2009/12/
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Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus Inra
Tocchini-Valentini, G.D.; Rochel, N.; Escriva, H.; Germain, P.; Peluso-Iltis, C.; Paris, M.; Sanglier-Cianferani, S.; Van Dorsselaer, A.; Moras, D.; Laudet, V..
Retinoid X nuclear receptors (RXRs), as well as their insect orthologue, ultraspiracle protein (USP), play an important role in the transcription regulation mediated by the nuclear receptors as the common partner of many other nuclear receptors. Phylogenetic and structural studies have shown that the several evolutionary shifts have modified the ligand binding ability of RXRs. To understand the vertebrate-specific character of RXRs, we have studied the RXR ligand-binding domain of the cephalochordate amphioxus (Branchiostoma floridae), an invertebrate chordate that predates the genome duplication that produced the three vertebrates RXRs (α, β, and γ). Here we report the crystal structure of a novel apotetramer conformation of the AmphiRXR ligand-binding...
Tipo: Journal Article Palavras-chave: AMPHIOXUS; PHYLOGÉNÉTIQUE; RÉCEPTEUR NUCLÉAIRE; RETINOID X.
Ano: 2009 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009bd3477f4&uri=/notices/prodinra1/2010/11/
Registros recuperados: 4
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