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	Provedor de dados BJID (2) Autor Deng,Hong (2) Li,Zongfang (2) Fanpu,Ji (1) Huang,Na (1) Ji,Fanpu (1) Yu,Shanshan (1) Zhang,Shu (1) Zhao,Wenxue (1) Mais... Palavra-chave Adverse drug reaction (1) Antiviral therapy (1) Cardiotoxicity (1) Hepatitis C virus (1) Pegylated interferon (1) Splenectomy (1) Thrombocytopenia (1) Thyroid dysfunction (1) Mais... Tipo do documento Info:eu-repo/semantics/other (1) Info:eu-repo/semantics/report (1) Ano 2014 (1) 2013 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Dilated cardiomyopathy and hypothyroidism associated with pegylated interferon and ribavirin treatment for chronic hepatitis C: case report and literature review BJID Zhao,Wenxue; Ji,Fanpu; Yu,Shanshan; Li,Zongfang; Deng,Hong. Pegylated interferon alpha (Peg IFN-α) in combination with ribavirin is the backbone of treatment in chronic hepatitis C (CHC). Cardiotoxicity due to interferon therapy is rare. The most frequent cardiovascular complications are arrhythmias and ischemic manifestations. Cardiomyopathy is extremely rare but can be life threatening. We present the case of a 41-year-old female patient with CHC in whom Peg IFN-α induced dilated cardiomyopathy and hypothyroidism. Chest radiography showed an enlarged and globular cardiac silhouette and pulmonary congestion. Echocardiography showed decreased left ventricular systolic function with an ejection fraction of 32% and fractional shortening of 15%. Cardiomyopathy had a complete remission after cessation of antiviral... Tipo: Info:eu-repo/semantics/report Palavras-chave: Pegylated interferon; Adverse drug reaction; Cardiotoxicity; Thyroid dysfunction. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100110 Splenectomy prior to antiviral therapy in patients with hepatitis C virus related decompensated cirrhosis BJID Fanpu,Ji; Zhang,Shu; Huang,Na; Deng,Hong; Li,Zongfang. Patients with hepatitis C virus-related decompensated cirrhosis can benefit frominterferonbased antiviral therapy, but the common complication of cytopenia is a contraindication for this treatment. Splenectomy prior to interferon therapy may alleviate this problem. To investigate whether splenectomy improves the efficacy of antiviral therapy, 13 interferonnaïve hepatitis C virus decompensated cirrhotic patients underwent splenectomy between January 2008 and January 2011, followed 1-3 months later by an interferon-based therapeutic regimen (pegylated/standard interferon-α combined with ribavirin for 48 weeks). Ten (76.9%) of the patients developed postoperative complications, which included minor portal vein thrombosis (2/13, 15.4%) and transient ascites... Tipo: Info:eu-repo/semantics/other Palavras-chave: Hepatitis C virus; Thrombocytopenia; Splenectomy; Antiviral therapy. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500014 Registros recuperados: 2 Primeira ... 1 ... Última

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