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Quality evaluation of simvastatin compounded capsules BJPS
Marques-Marinho,Flávia Dias; Zanon,José Carlos da Costa; Sakurai,Emilia; Reis,Ilka Afonso; Lima,Angélica Alves; Vianna-Soares,Cristina Duarte.
Simvastatin is commercially available as tablets and compounded capsules in Brazil. Very few reports regarding these capsules' quality, and consequently their efficacy, are available. The pharmaceutical quality of 30 batches of 20 mg simvastatin capsules from the market was evaluated by weight determination, content uniformity, disintegration (Brazilian Pharmacopeia), assay and dissolution test (USP32 tablet monograph). A HPLC method was developed for assay, content uniformity and dissolution test, and specifications were also established. Out of the 30 batches evaluated, 29 showed capsule disintegration within 45 min and individual weight variation was within ±10% or ±7.5% relative to average weight, for < or &gt; 300 mg, respectively. Only 27...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Compounded simvastatin capsules; Quality control; RP-HPLC.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000300007
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