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| Bezerra,D.P.; Castro,F.O.; Alves,A.P.N.N.; Pessoa,C.; Moraes,M.O.; Silveira,E.R.; Lima,M.A.S.; Elmiro,F.J.M.; Costa-Lotufo,L.V.. |
| Piplartine {5,6-dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)pyridinone} and piperine {1-5-(1,3)-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl]piperidine} are alkaloid amides isolated from Piper. Both have been reported to show cytotoxic activity towards several tumor cell lines. In the present study, the in vivo antitumor activity of these compounds was evaluated in 60 female Swiss mice (N = 10 per group) transplanted with Sarcoma 180. Histopathological and morphological analyses of the tumor and the organs, including liver, spleen, and kidney, were performed in order to evaluate the toxicological aspects of the treatment with these amides. Administration of piplartine or piperine (50 or 100 mg kg-1 day-1 intraperitoneally for 7 days starting 1... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Piplartine; Piperine; Antitumor activity; Toxicity. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000600014 |
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