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Branched-chain fatty acids, increased in tears of blepharitis patients, are not toxic for conjunctival cells Inra
Joffre, C.; Souchier, M.; Leclere, L.; Buteau, B.; Grégoire, S.; Lizard, G.; Montange, T.; Acar, N.; Bron, A.; Creuzot Garcher, C.; Diebold, Y.; Bretillon, L..
Aim: The composition of the meibum of blepharitis patients is characterised by increased levels of branched-chain fatty acids (BCFAs) that return to normal values in patients treated with cyclins and lid hygiene. The aim of this study was to determine if BCFAs had toxic effects on conjunctival cells related to the disease.Methods: Chang and IOBA-NHC conjunctival human cells were treated with BCFAs (isoC16 and isoC20) or palmitic acid as a control for 4 h or 24 h at 50 μM or 100 μM. Morphological and functional changes were investigated by measuring mitochondrial dehydrogenase activity, cell permeability, mitochondrial depolarisation, chromatin condensation, IL-1β and reactive oxygen species production.Results: None of the fatty acids modified the...
Tipo: Journal Article Palavras-chave: DRY EYE; BENZALKONIUM CHLORIDE; EPITHELIAL-CELLS; MUSCLE CELLS; LIPID LAYER; APOPTOSIS; MEMBRANE; MARKER.
Ano: 2009 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20105cdf51fe&uri=/notices/prodinra1/2010/07/
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Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol Inra
Dugas, B.; Charbonnier, S.; Baarine, M.; Ragot, K.; Delmas, D.; Menetrier, F.; Lherminier, J.; Malvitte, L.; Khalfaoui, T.; Bron, A.; Creuzot Garcher, C.; Latruffe, N.; Lizard, G..
Background and aimsOxysterols are assumed to play important roles in age-related macular degeneration, a major cause of blindness. So we characterized the cytotoxic, oxidative, inflammatory, and angiogenic activities of oxysterols (7β-hydroxycholesterol (7β-OH), 7-ketocholesterol (7KC), 25-hydroxycholesterol (25-OH)) in human retinal ARPE-19 cells, and evaluated the protective effects of resveratrol (Rsv: 1 μM), a polyphenol from red wine.MethodsARPE-19 cells were treated with 7β-OH, 7KC, or 25-OH (5–40 μg/mL; 24–48 h) without or with Rsv. Cell viability was determined using trypan blue and the MTT assay. Cell death was characterized by electron microscopy and in situ detection of activated caspases with fluorochrome-labeled inhibitors of caspases....
Tipo: Journal Article Palavras-chave: CELLULES RÉTINIENNES; DEGENERESCENCE MACULAIRE; DMLA ARPE-19 CELLS; CASPASE-INDEPENDENT CELL DEATH; INFLAMMATORY CYTOKINES; OXYSTEROLS; PHOSPHOLIPIDOSIS; RESVERATROL; REACTIVE OXYGEN SPECIES; VEGF.
Ano: 2010 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD201135a1139e&uri=/notices/prodinra1/2011/06/
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