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| Rodríguez-Martínez,M.; Torres-Rodríguez,M.L.; Brito-Orta,M.D.; López-Rodriguez,J.F.; Rodríguez-Pérez,A.S.; Calvo-Turrubiartes,M.Z.; Llamazares-Azuara,L.. |
| There is no index or criterion of aortic barodenervation, nor can we differentiate among rats that have suffered chronic sham, aortic or sino-aortic denervation. The objective of this study was to develop a procedure to generate at least one quantitative, reproducible and validated index that precisely evaluates the extent of chronic arterial barodenervation performed in conscious rats. Data from 79 conscious male Wistar rats of about 65-70 days of age with diverse extents of chronic arterial barodenervation and used in previous experiments were reanalyzed. The mean arterial pressure (MAP) and the heart rate (HR) of all rats were measured systematically before (over 1 h) and after three consecutive iv bolus injections of phenylephrine (PHE) and sodium... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aortic denervation; Sinoaortic denervation; Effectiveness of barodenervation. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100008 |
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| Rodríguez-Pérez,A.S.; López-Rodríguez,J.F.; Calvo-Turrubiartes,M.Z.; Saavedra-Alanís,V.M.; Llamazares-Azuara,L.; Rodríguez-Martínez,M.. |
| This study determined whether clinical salt-sensitive hypertension (cSSHT) results from the interaction between partial arterial baroreceptor impairment and a high-sodium (HNa) diet. In three series (S-I, S-II, S-III), mean arterial pressure (MAP) of conscious male Wistar ChR003 rats was measured once before (pdMAP) and twice after either sham (SHM) or bilateral aortic denervation (AD), following 7 days on a low-sodium (LNa) diet (LNaMAP) and then 21 days on a HNa diet (HNaMAP). The roles of plasma nitric oxide bioavailability (pNOB), renal medullary superoxide anion production (RMSAP), and mRNA expression of NAD(P)H oxidase and superoxide dismutase were also assessed. In SHM (n=11) and AD (n=15) groups of S-I, LNaMAP-pdMAP was 10.5±2.1 vs 23±2.1 mmHg... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Salt-sensitive hypertension; Aortic barodenervation; Nitric oxide bioavailability. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000868 |
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